基于“毒损脑络”病机理论研制抗缺血性中风优效方剂的网络药理学研究思路  

Research design of network pharmacology developing effective TCM prescription for ischemic stroke based on pathogenesis theory of toxin damaging brain collaterals

作　　者：马克信[1] 王玉贤[1] 王飞雪[2] 韩振蕴[3] 

机构地区：[1]中国中医科学院临床基础医学研究所,北京100700 [2]北京中医药大学东直门医院,北京100700 [3]北京中医药大学东方医院,北京100078

出　　处：《北京中医药》2013年第7期487-489,共3页Beijing Journal of Traditional Chinese Medicine

基　　金：国家科技重大专项"重大新药创制"项目(2009ZX09103-401)

摘　　要：既往因传统中医学缺少对急性缺血性中风病理生理的重视,以致治疗方向不明确,加之对中药作用的靶点网络缺少整体把握,因而治疗效果不理想。"毒损脑络"病机理论从缺血性中风的核心病机入手,为中医药治疗急性缺血性中风指明了方向。中医复杂网络调控观和中药多靶点作用特点与网络药理学的特征相符,因而基于网络药理学对"解毒通络"优效抗缺血性中风方剂的研究,可能为抗缺血性中风药物的研发提供一条全新的思路。Traditional Chinese medicine（TCM） didn＇ t highlight the pathology and physiology of acute ischemic stroke in the past, so the treatment orientation was unclear;, additionally, it lacked the grasp of target network for Chinese medicine, as a result, the therapeutic effect was unsatisfactory. The pathogenesis theory, toxin damaging brain collaterals, provided a way for the TCM treatment of acute ischemic stroke by commencing from the core pathogenesis of ischemic stroke. The TCM complex network regulation theory and multiple targets function characteristic of Chinese medicine were consistent with network pharmacology, so the study of effective TCM prescription of removing toxin to dredge collaterals for ischemic stroke based on network pharmacology might provide a new approach on drug development for ischemic stroke.

关 键 词：缺血性中风 毒损脑络 网络药理学 中药 药物研发 

分 类 号：R255.2[医药卫生—中医内科学]