Biocompatibility of Mg-Nd-Zn-Zr alloy with rabbit blood  

作　　者：WANG YongPing OUYANG YuanMing HE YaoHua CHEN DaoYun JIANG Yao MAO Lin NIU JiaLin ZHANG Jian YUAN GuangYin 

机构地区：[1]Department of Orthopaedics, First Hospital of Lanzhou University [2]Department of Orthopaedics, Sixth People's Hospital of Shanghai Jiao Tong University [3]National Engineering Research Center of Light Alloys Net Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University

出　　处：《Chinese Science Bulletin》2013年第23期2903-2908,共6页

基　　金：supported by Major Basic Research Project of Shanghai Science and Technology Commission(11DJ1400304,11DJ1400301);the National Natural Science Foundation of China(81071452,81271961 and 81271998)

摘　　要：In this study, in vitro blood biocompatibility of Mg-Nd-Zn-Zr (JDBM) alloy was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed by blood cell aggregation, platelet adhesion, and protein adsorption. A titanium alloy was used as control. The results showed that the JDBM alloy did not induce significant blood cell aggregation, platelet adhesion, and protein adsorption comparison with the titanium alloy (P>0.05). Our data indicate that the JDBM alloy has excellent in vitro blood compatibility, and thus can be considered as a potential degradable biomaterial for medical applications with respect to hemocompatibility.In this study, in vitro blood biocompatibility of Mg-Nd-Zn-Zr （JDBM） alloy was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed by blood cell aggregation, platelet adhesion, and protein adsorption. A titanium alloy was used as control. The results showed that the JDBM alloy did not induce significant blood cell aggregation, platelet adhesion, and protein adsorption comparison with the titanium alloy （P〉0.05）. Our data indicate that the JDBM alloy has excellent in vitro blood compatibility, and thus can be considered as a potential degradable biomaterial for medical applications with respect to hemocompatibility.

关 键 词：生物相容性 钛合金 血液相容性 血小板粘附 蛋白质吸附 钕 镁 生物材料 

分 类 号：R318.08[医药卫生—生物医学工程] TG146.22[医药卫生—基础医学]