老年男性前列腺增生与脂肪因子及脂代谢关系的研究  

Role of Adipokines and Lipid Metabolism on Prostate Hyperplasia in Elderly Men

作　　者：翟宇强[1] 谭云鹤[1] 刘延[1] 石硕文[1] 曹志平[1] 杨平[1] 

机构地区：[1]西安市中心医院泌尿外科,陕西西安710003

出　　处：《昆明医科大学学报》2013年第6期94-96,115,共4页Journal of Kunming Medical University

基　　金：西安市社会发展引导计划项目(SF1201)

摘　　要：目的探讨老年男性前列腺增生患者脂肪因子及脂代谢关系,明确其高危因素.方法选择老年男性前列腺增生患者146例,根据BMI分为分为非肥胖组(A组)、肥胖组(B组),分别有77例、69例.选择无前列腺增生的正常非肥胖老年男性50例为C组.入选后分别检测3组对象血脂、血清内脂素、抵抗素、瘦素水平.结果 A组TG、TC较C组有增加(P<0.05),HDL较A组有下降(P<0.05);B组患者TG、TC、LDL较C组存在升高(P<0.05),HDL较C组存在下降(P<0.05),TG较A组存在升高(P<0.05).A组内脂素较C组有下降(P<0.05),抵抗素、瘦素较C组有上升(P<0.05);B组内脂素较C组有下降(P<0.01),抵抗素、瘦素较A组有上升(P<0.05),内脂素、瘦素水平比较A组,差异有统计学意义(P<0.05).内脂素与TG、TC呈负相关(P<0.01),与HDL呈正相关(P<0.05);抵抗素与TG、TC呈正相关(P<0.05),与HDL呈负相关(P<0.05).瘦素与TG、TC、LDL呈正相关(P<0.05).结论脂肪因子及脂代谢是老年男性前列腺增生发生的重要因素,纠正其代谢紊乱具有重要意义.Objective To investigate the role of adipokines and lipid metabolism on prostate hyperplasia in elderly men and make the high risk factors clear. Methods One hundred and forty-six patients with benign prostatic hyperplasia were divided into non-obese group （A） and the obese group （B） according to BMI, with 77 cases and 69 cases respectively. And fifty normal older men were enrolled in the group C. The levels of lipids, serum visfatin, resistin and leptin were detected. Results TG and TC in group A significantly increased compared with group C （P〈0.05） while HDL significantly decreased in group C （P〈0.05） . TG, TC and LDL in Group B significantly increased but HDL decreased compared with group C （P〈0.05） , and TG was significantly higher in Group B than that in group A （P 〈0.05） . Visfatin in group A significantly decreased but resistin and leptin increased compared with group C （P〈0.05） . Visfatin in group B significantly decreased compared with group C （P〈0.01） , but resistin and leptin significantly increased compared with group A （P〈0.05） . There were significant negative correlations between visfatin and TG, TC （P〈0.05） but positive correlation between visfatin and HDL （P〈0.05） . Resistin showed significant positive correlations with TG and TC （P〈0.05） and negative correlation with HDL （P〈0.05） . Leptin and TG, TC, LDL showed significant positive correlations （P 〈 0.05） . Conclusion Adipokines and lipid metabolism are the important factors for prostate hyperplasia in elderly men, and it is significant in correcting the metabolic disorders of them.

关 键 词：脂肪因子 血脂 前列腺增生 老年 

分 类 号：R697.3[医药卫生—泌尿科学]