活性炭胃肠灌洗治疗对有机磷中毒患者肝功能恢复的意义  

Significance of Activated Carbon Gastrointestinal Lavage Treatment for Patients with Organophosphorus Poisoning on Recovery of Liver Function

作　　者：任爱红[1] 杨艳[1] 

机构地区：[1]汉中市中心医院护理部,陕西汉中723000

出　　处：《昆明医科大学学报》2013年第6期155-157,共3页Journal of Kunming Medical University

基　　金：陕西省科学技术资助项目(961202y0646)

摘　　要：目的探讨活性炭胃肠灌洗治疗急性有机磷中毒所致肝损害的临床疗效.方法选择急性有机磷中毒所致肝损害患者128例,随机分成对照组和治疗组,每组各64例.对照组采用常规治疗方法;治疗组除采用上述治疗方法外,加活性炭吸附联合聚乙二醇电解质散导泻.监测2组患者肝功能指标谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBIL)及胆碱酯酶(ChE)活力,并进行比较.结果治疗组肝功能恢复较对照组有明显改善,转氨酶明显下降,差异有统计学意义(P<0.05).结论急性有机磷中毒患者给予活性炭吸附联合聚乙二醇电解质散导泻治疗,肝功能改善明显,安全有效.Objective To investigate the clinical efficacy of activated carbon gastrointestinal lavage on liver damage of acute organophosphorus poisoning. Methods 128 patients suffered from liver damage of acute organophosphorus poisoning were randomly divided into control and treatment groups, with 64 cases in each group. The control group was given conventional treatment methods, and the treatment group was given activated carbon adsorption combined with polyethylene glycol electrolyte bulk cathartic on the basis of conventional treatment. The activities of liver function indicators including alanine aminotransferase （ALT） , aspartate aminotransferase （AST） , alkaline phosphatase （ALP） , total bilirubin （TBIL） and cholinesterase （ChE） were detected and compared between the two groups. Results Compared with the control group, the liver functions of the treatment group showed significant improvement with an apparent decline in aminotransferase, and the difference was statistically significant （P〈0.05） Conclusion Activated carbon adsorption joint polyethylene glycol electrolyte bulk cathartic could be used to treat the liver damage of acute organophosphorus poisoning, which was safe and effective. After treatment, the liver functions of patients were improved significantly.

关 键 词：急性有机磷中毒 活性炭 胃肠灌洗 肝功能 

分 类 号：R996[医药卫生—毒理学]