组织弥散定量参数判断肝纤维化的价值评估  

The Value of Quantitative Parameter of Organization Diffusion Application in Diagnosing Liver Fibrosis

作　　者：丛淑珍[1] 裴书芳[1] 郭汉涛[1] 王敏[1] 李妙珊[1] 

机构地区：[1]广东省人民医院超声科,广州市510080

出　　处：《中国超声医学杂志》2013年第8期698-701,共4页Chinese Journal of Ultrasound in Medicine

基　　金：广东省科技计划项目(No.[2011]177)

摘　　要：目的探讨组织弥散定量参数蓝色区域所占面积百分比评估肝纤维化有无的最佳诊断界点及其诊断价值。方法慢性乙型肝炎患者70例,肝穿前均行组织弥散定量参数分析,用ROC曲线分析其诊断价值。所有病例均经病理证实。结果组织弥散定量参数蓝色区域所占面积百分比与肝组织纤维化病理分期的相关系数为0.906(P=0.000),蓝色区域所占面积百分比随着肝纤维化程度的上升而增高。组织弥散定量参数蓝色区域所占面积百分比诊断肝纤维化有无的最佳诊断界点为18.26%,其ROC曲线下面积为0.929,其敏感性、特异性、准确性分别为81.8%、96.2%、87.1%。结论组织弥散定量参数蓝色区域所占面积百分比为肝纤维化的评估提供了另一种新指标。Objective To explore the best cut-off point of the quantitative parameter of organization diffusion for differentiating liver fibrosis and to assess its diagnostic value. Methods Seventy patients with chronic hepatitis B were examined with the quantitative analysis of organization diffusion before liver biopsy, and made a ROC analysis of diag- nostic test. All cases confirmed by pathology. Results The coefficient correlation between the area percentage share of the blue region and the stages of liver fibrosis was 0. 906（P=0. 000）. 18. 26% was the best cut-off point of area percentage share of the blue region which was one parameter of the quantitative analysis of organization diffusion, the area under the curve of ROC was 0. 929 （P=0. 000）, and the sensitivity, specificity, accuracy were 81.8%, 96.2% and 87.1%, respectively. Conclusions The area percentage share of the blue region, which was one parameter of the quantitative analysis of organization diffusion, provides a new index for diagnosising liver fibrosis.

关 键 词：组织弥散定量参数 蓝色区域所占面积百分比 肝纤维化 

分 类 号：R445.1[医药卫生—影像医学与核医学] R575.2[医药卫生—诊断学]