头孢匹胺临床药物动力学研究  

Study on clinical pharmacokinetics of cefpiramide

作　　者：施耀国[1] 张菁[1] 孔维佳[1] 曹忆堇[1] 曹国英 张婴元[1] 

机构地区：[1]上海医科大学华山医院抗生素研究所,上海200040

出　　处：《中国抗生素杂志》2000年第4期294-297,共4页Chinese Journal of Antibiotics

摘　　要：为研究头孢匹胺在中国健康志愿者中的体内过程特点 ,对 8名男性受试者接受单剂静脉滴注头孢匹胺 1g后的药物动力学进行了研究 ,并以头孢哌酮为对照药 ,亦予以单剂静滴 1g。同时以高效液相色谱法和微生物法测定两药血、尿药物浓度。结果表明 ,头孢匹胺消除半减期较头孢哌酮者为长 ,两者分别为 (4 .6 6±0 .94)和 (1.97± 0 .35 ) h;头孢匹胺的 AUC较头孢哌酮为大 ,分别为 (841.39± 2 0 8.0 9)和 (2 89.10± 5 9.12 ) (h·mg) / L。两者均以非肾消除途径为主 ,头孢匹胺自尿中排出给药量的 (18.45± 2 .72 ) % ,头孢哌酮为 (2 3.2 3± 4.30 ) %。The pharmacokinetics of cefpiramide was studied in 8 healthy volunteers who received 1g of cefpiramide and cefoperazone by intravenous infusion respectively in crossway. The concentrations of cefpiramide and cefoperazone in serum and urine were measured by the method of high performance liquid chromatography and microbioassay. Results showed that the eliminated half life ( T 1/2 ) of cefpiramide was longer than that of cefoperazone, being (4.66±0.94) and (1.97±0.35)h respectively. The area under curve (AUC) of cefpiramide was larger than that of cefoperazone, being (841.39±208.09) and (289.10±59.12)(h·mg)/L respectively. Both cefpiramide and cefoperazone were mainly excreted via non renal way, only (18.45± 2.72)% of cefpiramide and (23.23±4.30)% of cefoperazone were recovered from urine.

关 键 词：头孢匹胺 头孢哌酮 临床药物动力学 

分 类 号：R978.11[医药卫生—药品] R969.1[医药卫生—药学]