闭合性颅脑外伤患者病程与P_(300)之间关系的研究  

STUDY ON THE RELATIONSHIP BETWEEN THE COURSE OF DISEASE AND P_(300) OF PATIENTS WITH CLOSED HEAD INJURY

作　　者：赵向东[1] 朱文华[1] 张美莲[1] 周冰玲[1] 

机构地区：[1]江苏省泰兴市人民医院神经内科

出　　处：《现代电生理学杂志》2000年第1期12-16,共5页Journal of Modern Electrophysiology

摘　　要：目的:研究闭合性颅脑外伤患者病程与P_(300)之间的关系,探讨此类患者作P_(300)测定的最佳时间。方法:应用Medicid-03E脑诱发电位仪测定518例闭合性颅脑外伤患者的视觉(图像)刺激诱发的P_(300)波之潜伏期和波幅。对其中异常的385例与214例正常对照组作比较,并比较不同伤情、伤后不同时间患者的P_(300)波。结果:病人组P_(300)波潜伏期较正常对照组明显延长(P<0.001),波幅亦明显降低(P<0.01),其P_(300)改变在伤后25至48小时内明显,尤以伤后有昏迷者更为突出。随着时间的延长,P_(300)波异常程度有所改善。结论:P_(300)波的变化可作为判断闭合性颅脑外伤患者脑认知功能变化的一项客观指标,其中伤后25至48小时内测定具有更高的价值,根据P_(300)波的变化能判断患者的伤情和预后。Objectives:To study the relationship between the course of disease and P300 of patients with closed head injury and assess optimum time for P300 measuring. Methods: With medicid-03E brain evoked potential instrument of Neuronic Company,the latency and the amplitude of P300 evoked by visual (image) were recorded in 518 patients with closed head injury,in which 385 abnormal cases were compared with 214 normal subjects and compared with the P300 during different condition of injury and different time after injury. Results: The P300 latency in patient group was significantly prolonged as compared with the control group (P<0. 001) and the amplitude was significantly decreased (P< 0.01). The change of P300 was significant from 25 to 48 hours after injury, especially in patients with idiopathic coma. With the prolonged of the time ,the abnormal level of P300 was improved. Conclusions:The changes of P300 might be taken as an objective index of measuring the changes of the brain cognition in patients with closed head injury and those from 25 to 48 hours after injury were more valuable. The changes of P300 were useful and helpful for judging patient's condition and prognosis.

关 键 词：闭合性颅脑外伤 P300 认知功能 病程 

分 类 号：R651.15[医药卫生—外科学]