硫普罗宁与甘草酸二铵对抗结核药物性肝病的疗效研究  

Effect study of tiopronin and diammonium glycyrrhizinate on anti-tuberculosis drug-induced liver disease

作　　者：程向东[1] 宓丹[2] 李继承[3] 

机构地区：[1]湖北省孝感市中心医院基建办,湖北孝感432000 [2]湖北省孝感市中心医院信息科,湖北孝感432000 [3]浙江大学医学院基础医学部,浙江杭州310058

出　　处：《中国医药导报》2013年第23期83-85,共3页China Medical Herald

基　　金：浙江省重大科研专项和优先主题计划项目(编号:2009C03011-3)

摘　　要：目的探究硫普罗宁与甘草酸二铵治疗结核药物性肝病的临床治疗效果。方法将湖北省孝感市中心医院2010年3月～2011年3月收治的78例结核药物性肝病患者分为两组,A组39例患者给予硫普罗宁进行治疗,B组39例患者给予甘草酸二铵进行治疗,观察两组患者丙氨酸转氨酶(ALT)、门冬酸转氨酶(AST)和血清白蛋白(ALB)以及白球比(A/G)与总胆红素(SB)等临床指标。结果 A组临床治疗总有效率为94.9%,B组临床治疗总有效率为92.3%。A组临床治疗总有效率与B组临床治疗总有效率比较差异无统计学意义(P>0.05);A组与B组患者治疗后ALT、AST、ALB、A/G、SB水平较治疗前有明显的改善,数据比较差异有统计学意义(P<0.05),;治疗后A组与B组ALT、AST和SB比较差异无统计学意义(P>0.05),;而两组ALB、A/G比较差异有统计学意义(P<0.05)。结论临床中采取硫普罗宁与甘草酸二铵对结核药物性肝病的转氨酶治疗具有较好的应用效果,且硫普罗宁对促进患者肝脏蛋白的合成效果更加明显。Objective To investigate the clinical effect of tiopronin and diammonium glycyrrhizinate in the treatment of anti-tuberculosis drug-induced liver disease.Methods 78 cases of patients with anti-tuberculosis drug-induced liver disease,who treated in Xiaogan Central Hospital of Hubei Provinve from March 2010 to March 2011,were divided in to two groups.39 cases in group A were treated with tiopronin,39 cases in group B were given diammonium gly cyrrhizinate.Patients in two groups were observed with alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,serum albumin（ALB）,the ratio of albumin and globulin（A/G）,total bilirubin（SB） and other clinical indicators.Results The clinical total effective rate in group A was 94.9%,and that in group B was 92.3%.Comparison of clinical total effective rate between group A and group B showed no significant difference（P 0.05）,the difference was not statistically significant.After treatment,ALT,AST,ALB,A/G and SB level in group A and group B patients were sig nificantly improved than those before treatment.And comparison of data showed a significant difference（P 0.05）,it was statistically significant.After treatment,comparison of ALT,AST and SB between group A and group B showed no significant difference（P 0.05）,it was not statistical significant.But comparison of ALB and A/G between two groups showed an obvious difference（P 0.05）,it was statistically significant.Conclusion Tiopronin and diammonium glycyrrhizinate have a better application effect in treatment of transaminase of tuberculosis drug-induced liver disease in clinic,and tiopronin has a more obvious effect on promoting liver protein synthesis.

关 键 词：结核药物性肝病 硫普罗宁 甘草酸二铵 临床疗效 

分 类 号：R595.3[医药卫生—内科学]