血清载脂蛋白A1、载脂蛋白B及其比值与冠脉病变程度相关性分析  

Correlation of serum ApoB and ApoA1 level,ApoA1/ApoB ratio with severity of coronary artery stenosis

作　　者：刘姗姗[1] 王璐[1] 邱建平 

机构地区：[1]宁夏医科大学研究生学院,宁夏银川750004 [2]上海公利医院心内科,上海200135

出　　处：《中国实验诊断学》2013年第7期1216-1218,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的研究血清载脂蛋白B(ApoB)、载脂蛋白A-1(ApoA1)及载脂蛋白A1/载脂蛋白B(ApoA1/ApoB)值与冠脉粥样硬化病变及其严重程度的关系。方法 510例行冠脉造影检查的住院患者根据冠脉造影结果分为单支病变组(132例)、多支病变组(266例)和对照组(112例),比较血清ApoB、ApoA1水平及ApoA1/ApoB值在各组中的变化,分析其血清水平与冠脉狭窄严重程度的相关性。结果①冠心病单支病变组血清ApoB(0.98±0.35g/L vs0.76±0.48g/L,P<0.05)和多支病变组血清ApoB(1.85±0.31g/L vs 0.67±0.48g/L,P<0.05)均显著高于对照组,血清ApoB水平与冠脉病变支数(r=0.27,P<0.05)及狭窄程度(r=0.32,P<0.01)呈显著正相关性。②CHD组血清ApoA1和ApoA1/ApoB值显著低于对照组,与冠脉病变支数及狭窄程度呈负相关性。结论血清ApoB水平反映了动脉粥样硬化的程度,与冠脉病变严重程度呈正相关,血清ApoA1水平和ApoA1/ApoB值与冠脉病变严重程度呈负相关。Objective To investigate the correlation of serum apolipoprotion B（ApoB） levels,apolipoprotion A-land apolipoprotion A1/apolipoprotion B（ApoA1/ApoB） ratio with coronary heart disease（CHD）. Methods A total of 510 hospitalized patients were divided into three groups by the results of CAG：control group（n= 112） ,single-vessel group （n=132） and multi-vessel group（n= 266）. Correlation and regression analysis were applied to find the correlation be- tween the serum levels of ApoB and ApoA1, ApoB/ApoA1 ratio and the vessels narrowed and narrowing degree in CHD. Results （D The levels of plasma ApoB were significantly higher in single-vessel group[（0.95±0. 35） g/L vs （0.67±0.48） g/L,P〈0.05land multi-vessel group[（1.85±0.31） g/L vs （0.67±0.48） g/L,P〈0.05]than those of the control group. Among patients with CHD, ApoB were also positively correlated to the narrowing vessel number（r= 0.27,P〈0.05）and the narrowing degree（r=0.32,P？ 0.01）. @The levels of plasma ApoA1 and ApoB/ApoA1 ratio in the CHD group are lower than the control group, and there exists a negative correlation between it and the narrowing vessel number,the narrowing degree. Conclusion Plasma ApoB could reflect the situation of carotid atherosclerosis, and there exists a positive correlation between Plasma ApoB and the severity of coronary artery stenosis, there exists a negative correlation between ApoA1 ,ApoB/ApoA1 ratio and the severity of coronary artery stenosis.

关 键 词：血清载脂蛋白B 载脂蛋白A-1 载脂蛋白A1 载脂蛋白B值 冠状动脉病变程度 

分 类 号：R541.4[医药卫生—心血管疾病]