慢性硬膜下血肿发病机制的研究进展  

The Research Progress of the Pathogenesis of Chronic Subdural Hematoma

作　　者：武琼[1] 崔大明[2] 楼美清[2] 

机构地区：[1]同济大学,上海200092 [2]同济大学附属上海市第十人民医院神经外科,上海200072

出　　处：《医学综述》2013年第14期2502-2504,共3页Medical Recapitulate

基　　金：国家自然科学基金(81201979)

摘　　要：颅内慢性硬膜下血肿的发病机制目前尚未明确,近年来的研究进展显示其涉及多种因素和多个步骤。高龄、外伤、抗凝治疗、饮酒等是其重要的易患因素。血肿外膜新生血管形成及再出血、局部炎性反应、局部纤溶亢进等机制在解释慢性硬膜下血肿致病的机制方面具有重要作用,相关的细胞因子日益成为研究的热点。发病机制的研究进展将会为建立更加有效而安全的治疗策略提供新的思路。The pathogenesis of intracranial chronic subdural hematoma（CSDH） is not yet clear,and recent studies indicate that multiple factors and multiple steps are involved.Advanced age,trauma,anticoagulant therapy,alcohol consumption are important predisposing factors of CSDH.Hematoma adventitial neovascular formation and rebleeding,local inflammatory reaction,local hyperfibrinolysis mechanism play important roles in explaining the pathogenic mechanism of CSDH,and the related cytokines have increasingly become a hot research spot.The pathogenesis research progress will provide new ideas for the establishment of more effective and safe treatment strategies.

关 键 词：慢性硬膜下血肿 易患因素 发病机制 

分 类 号：R651.1[医药卫生—外科学]