心肌细胞钙循环调节机制的研究进展  

Research Progress in Regulatory Mechanism of Calcium Circulation in Myocardial Cell

作　　者：朱蔚琳[1] 何并文[2] 

机构地区：[1]广西壮族自治区人民医院麻醉科,南宁530021 [2]广西医科大学附属肿瘤医院麻醉科,南宁530021

出　　处：《医学综述》2013年第14期2530-2532,共3页Medical Recapitulate

摘　　要：钙循环包括钙释放、回摄与存储三部分,在维持心肌细胞正常生理兴奋-收缩耦联中有重要作用。钙循环的调节机制复杂,目前对钙循环机制的研究也不断深入。在一些病理改变如心力衰竭、心肌肥大和缺血/再灌注损伤的诊疗中,了解钙循环异常调节机制的最新进展,如心肌葡萄糖转运蛋白5对钙释放的影响、钙泄漏中兰尼碱受体2敏感性下降、"类夸克"现象及线粒体参与肌质网钙循环等,对更好地做好心肌保护具有重要意义。Ca circling includes Ca release,uptake and storage procedure,which play an important role in keeping normal excitation—contraction coupling in myocardial cells.Ca cycle regulatory mechanism is complicated and has seen some important progression presently.Under some pathological states,such as heart failure,myocardial hypertrophy and ischemia-reperfusion injury in myocardial cells,etc..Understanding the latest progress of abnormal Ca circulation regulatory mechanisms such as： glucose transport protein 5 effecting Ca release;Ca leakage caused ryanodine receptor 2 sensitivity decrease,quasi quark phenomenon and plastochondria participating sarcoplasmic reticulum Ca circling etc.,is of great significance for myocardial protection.

关 键 词：钙循环 调节机制 心肌细胞 

分 类 号：R331[医药卫生—人体生理学]