巨噬细胞移动抑制因子、肿瘤坏死因子α在强直性脊柱炎中的表达及临床意义  

Expression and Its Clinical Significance of Serum MIF and TNF-αin Patients with Ankylosing Spon-dylitis

作　　者：丁怡[1] 陈璇[2] 王颖[1] 张静女[1] 冯冬梅[1] 蔡钦泉[1] 

机构地区：[1]深圳市罗湖区人民医院风湿科,广东深圳518000 [2]新乡医学院第三附属医院儿科,河南新乡453003

出　　处：《医学综述》2013年第14期2615-2617,共3页Medical Recapitulate

基　　金：2011年深圳市科技计划项目(201103283)

摘　　要：目的探讨血清巨噬细胞移动抑制因子(MIF)、肿瘤坏死因子α(TNF-ɑ)在强直性脊柱炎(AS)中的表达及临床意义。方法选择2009年1月至2012年12月在深圳市罗湖区人民医院风湿科门诊及住院治疗的AS患者40例,依据Bath AS活动指数分为活动期组30例,静止期组10例,另外选取体检中心健康自愿者30例作为正常对照组。采用酶联免疫吸附试验(ELISA)检测上述受试者血清MIF及TNF-ɑ水平,并进行比较。结果活动期组患者血清MIF及TNF-α水平显著高于正常对照组及静止期组(P<0.05);按骶髂关节CT结果Ⅰ、Ⅱ级AS患者血清MIF及TNF-α水平显著高于正常对照组(P<0.05),AS患者血清MIF和TNF-α水平与红细胞沉降率、C反应蛋白呈正相关(P<0.05)。结论 MIF和TNF-α在AS患者活动期高表达,提示其可能参与AS慢性进展性炎症的过程。Objective To investigate the expression and clinical significance of serum macrophage migration inhibitory factor（MIF） and tumor necrosis factor-alpha（TNF-ɑ） in patients with ankylosing spondylitis（AS）.Methods Forty patients with AS admitted to Shenzhen Luohu People Hospital from January 2009 to December 2012 were selected and divided into initial treatment group（group A,n = 30） and treatment group（group B,n =10）.Another thirty healthy persons were included as control group（group C）.The serum levels of MIF and TNF-ɑ were tested by ELLSA technique.Results The MIF and TNF-ɑ level in group A were significantly higher than those in group B and group C（P 0.05）.According to the CT result of sacroiliac joint： the MIF and TNF-ɑ level of patients with level Ⅰ/level Ⅱ AS were higher than those in group C（P 0.05）.The MIF and TNF-ɑ level of patients with AS were positively correlated with ESR and CRP（P 0.05）.Conclusion MIF and TNF-ɑ are highly expressed during AS active period,indicating that they may be involved in the pathogenesis of the chronic progressive inflammation of AS.

关 键 词：强直性脊柱炎 巨噬细胞移动抑制因子 肿瘤坏死因子Α 

分 类 号：R539[医药卫生—内科学]