抗精子抗体阳性男性不育患者血清、精液中SOD活性和MDA含量的变化  

Changes of superoxide dismutase activity and MDA level in serum and semen of antisperm antibody positive male infertility

作　　者：边淑玲[1] 姚兰春[1] 田淑君[1] 倪江[1] 张玮[2] 陈亮[2] 刘国艺 李凯 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150086 [2]哈尔滨医科大学附属第二医院妇产科,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2000年第4期281-282,共2页Journal of Harbin Medical University

摘　　要：目的研究抗精子抗体阳性男性患者不育的原因。方法应用黄嘌呤氧化酶法，测定抗精子抗体（ＡｓＡｂ）阳性男性不育患者及正常生育男性血清、精液中超氧化物歧化酶（ＳＯＤ）活性的变化。应用比色方法测定过氧化脂质降解产物中丙二醛（ＭＤＡ）含量变化。结果 ＡｓＡｂ阳性组与正常生育组比较，血清、精液中ＳＯＤ活性均明显降低，ＭＤＡ均明显升高。结论ＡｓＡｂ阳性引起的不育可能与氧自由基增多有一定关系。Objective To study the reasons that antisperm antibody positive leads to male infertility. Methods The changes of superoxide dismutase(SOD) activity and MDA level in serum and semen of antisperm antibody(AsAb) positive male infertility and fertility were observed by biochemistry method. Results SOD activity decreased and MDA level increased significantly in serum and semen of AsAb positive male infertility compared with fertility. Conclusion The changes of SOD activity and MDA level in serum and semen may play a role in AsAb positive male infertility.

关 键 词：抗精子抗体 不育症 男性不育症 SOD MDA 

分 类 号：R698.2[医药卫生—泌尿科学]