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机构地区:[1]盐城市第一人民医院药剂科,江苏省盐城224006
出 处:《中国基层医药》2013年第17期2563-2565,I0001,共4页Chinese Journal of Primary Medicine and Pharmacy
基 金:江苏省盐城市医学科技发展计划项目(盐科发[2011]138号)
摘 要:目的 探讨高效液相色谱法(HPLC)测定鼻窦炎合剂中的盐酸麻黄碱浓度的效果.方法 色谱柱为DiamonsilTM C18柱(250 mm×4.6 mm,5μm),柱温为30℃,检测波长为210 nm,进样量20μl,流动相为乙腈-0.05%磷酸进行洗脱.结果 盐酸麻黄碱在0.011~0.277 mg/ml范围内呈良好的线性关系.15批鼻窦炎合剂中盐酸麻黄碱质量范围为0.10 ~0.23 mg/ml.结论 该方法操作简便、快速、准确,适用于鼻窦炎合剂中盐酸麻黄碱的含量测定.Objective To explore the application of HPLC method in the determination of contents of ephedrine hydrochloride in Bidouyan mixture.Methods A HPLC method detected by one wavelength-210 nm for ephedrine hydrochloride had been developed.The chromatographic procedure for determination was carried out using DiamonsilTM C 18 (250mm x 4.6mm,5 μm) as an analytic column gradient eluted with a mixture consisting of acetonitrile and 0.05% H3PO4.Results The ranges of calibration curve of ephedrine hydrochloride was 0.011 ~ 0.277mg/ml.The established HPLC method was applied to determine 15 samples of Bidouyan mixture.The results showed that the ranges of ephedrine hydrochloride was 0.10 ~ 0.23mg/ml.Conclusion A simple,effective and feasible HPLC method to determine the contents of ephedrine hydrochloride was established for the quality control of Bidouyan mixture.
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