鼻窦炎合剂的质量控制研究  

Quality control study on Bidouyan mixture

作　　者：陈迎平 张霞 

机构地区：[1]盐城市第一人民医院药剂科,江苏省盐城224006

出　　处：《中国基层医药》2013年第17期2563-2565,I0001,共4页Chinese Journal of Primary Medicine and Pharmacy

基　　金：江苏省盐城市医学科技发展计划项目（盐科发[2011]138号）

摘　　要：目的 探讨高效液相色谱法（HPLC）测定鼻窦炎合剂中的盐酸麻黄碱浓度的效果.方法 色谱柱为DiamonsilTM C18柱（250 mm×4.6 mm,5μm）,柱温为30℃,检测波长为210 nm,进样量20μl,流动相为乙腈-0.05％磷酸进行洗脱.结果 盐酸麻黄碱在0.011～0.277 mg/ml范围内呈良好的线性关系.15批鼻窦炎合剂中盐酸麻黄碱质量范围为0.10 ～0.23 mg/ml.结论 该方法操作简便、快速、准确,适用于鼻窦炎合剂中盐酸麻黄碱的含量测定.Objective To explore the application of HPLC method in the determination of contents of ephedrine hydrochloride in Bidouyan mixture.Methods A HPLC method detected by one wavelength-210 nm for ephedrine hydrochloride had been developed.The chromatographic procedure for determination was carried out using DiamonsilTM C 18 （250mm x 4.6mm,5 μm） as an analytic column gradient eluted with a mixture consisting of acetonitrile and 0.05％ H3PO4.Results The ranges of calibration curve of ephedrine hydrochloride was 0.011 ～ 0.277mg/ml.The established HPLC method was applied to determine 15 samples of Bidouyan mixture.The results showed that the ranges of ephedrine hydrochloride was 0.10 ～ 0.23mg/ml.Conclusion A simple,effective and feasible HPLC method to determine the contents of ephedrine hydrochloride was established for the quality control of Bidouyan mixture.

关 键 词：鼻窦炎合剂 盐酸麻黄碱 色谱法 高效液相 质量控制 

分 类 号：R286[医药卫生—中药学]