丙种球蛋白治疗重症EV71感染疗效评估  

Evaluation of intravenous immunoglobulin in the treatment of severe EV71 infection in children

作　　者：李素华[1] 陈益平[1] 汪洪姣[1] 陈雪夏[1] 林海龙[1] 夏蝉[1] 

机构地区：[1]温州医学院附属育英儿童医院感染科,浙江省温州325027

出　　处：《中国基层医药》2013年第17期2569-2571,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：浙江省温州市科技计划项目（Y20110140）

摘　　要：目的 评估静脉注射用丙种球蛋白（IVIG）治疗重症EV71感染手足口病患儿的疗效.方法 回顾性分析重症EV71感染手足口病患儿的临床资料,按收治时间及治疗原则不同分为2010年组及2012年组,2010年组患儿常规应用MG治疗,2012年组患儿仅对有发展成危重症可能的患儿应用MG,比较两组患儿的显效率、有效率、无效率、危重症发生率及病死率.结果 两组患儿显效率（86.0％与85.2％）、有效率（9.6％与11.8％）、无效率（4.4％与3.0％）、危重症发生率（4.0％与2.2％）差异均无统计学意义（Х^2=0.011、1.269、1.657、3.304,均P＞0.05）；2010年组病死率（2.8％）高于2012年组（0.6％）（Х^2=8.213,P＜0.05）.结论 IVIG在治疗重症EV71感染手足口病患儿中无优势,不建议使用.Objective To evaluate the efficacy of intravenous immunoglobulin （IVIG） in the treatment of severe EV71 infection in children.Methods The clinical data of children with severe EV71 infection,who admitted in our hospital from January 2010 to November 2012 were retrospectively analyzed.According to the time of admission and treatment principles,the patients were divided into the 2010 group and the 2012 group.The patients of the 2010 group routinely received IVIG treatment,but patients in the 2012 group received IVIG treatment in serious condition.The obvious effective rate,effective rate,ineffective rate,the incidence rate of critically ill and mortality of the two groups were compared.Results There were no significant differences in the obvious effective rate （86.0% and 85.2%）,effective rate （9.6% and 11.8%）,ineffective rate （4.4% and 3.0%）,the incidence rate of critically ill （4.0% and 2.2%） between the two groups （Х^2 =0.011,1.269,1.657,3.304,all P 〉 0.05）.The mortality of the 2010 group （2.8%） was higher than that of the 2012 group （0.6%）（Х^2 =8.213,P 〈0.05）.Conclusion IVIG has no effect on patients with severe EV71 infection,and is not recommended.

关 键 词：肠道病毒71型 手足口病 丙种球蛋白类 

分 类 号：R725.1[医药卫生—儿科]