51例石油作业习惯性流产女性淋巴细胞遗传损伤研究  

Study on the lymphocytes cytogenetic damage of fifty - one habitual abortion women in petroleum operations

作　　者：慕明涛[1] 霍满鹏[1] 蒲力群[1] 张静[1] 刘俊俊[1] 

机构地区：[1]延安大学医学院医学遗传学与细胞生物学教研室,陕西延安716000

出　　处：《中国优生与遗传杂志》2013年第8期38-38,10,共2页Chinese Journal of Birth Health & Heredity

基　　金：延安大学自然科学研究计划项目(YD2011-04)

摘　　要：目的分析石油作业女性习惯性流产与淋巴细胞姐妹染色单体互换(SCE)的关系。方法随机选择习惯性流产的石油作业女性51人和正常的育龄女性20人,检测其外周血淋巴细胞姐妹染色单体互换,记数SCE发生率。结果观察组的外周血淋巴细胞SCE发生率为8.62±0.75,明显高于对照组(P<0.05)。结论 SCE的发生可作为石油作业习惯性流产女性染色体结构稳定性的检测指标。石油作业环境中的某些有害物质可造成女性细胞遗传损伤。Objective： Analysis of the impact of sister chromatid exchange（SCE） in peripheral blood lymphocytes among habitual abortion women in the petroleum operations.Methods： Fifty-one women with habitual abortion and 20 normal women with childbearing age were selected randomly as observation group and control group respectively.The peripheral blood lymphocytes from them were cultivated and detected by SCE test method,and count the frequency of them.Results： The frequency of SCE was 8.62 ± 0.75,it＇s frequency in observation group were higher than that in control group（P 0.05）.Conclusion： The incidence of SCE can be used as the detective index of chromosome＇s structural stability of women with habitual abortions who are exposed to the environment in petroleum operations of certain hazardous substances which can results in DNA damage.

关 键 词：习惯性流产 姐妹染色单体互换 遗传损伤 

分 类 号：R714.21[医药卫生—妇产科学]