血红蛋白氧载体的抗氧化研究进展  

Research progress in anti - oxidation of hemoglobin - based oxygen carriers

作　　者：宋俊贞[1] 魏文志[2] 

机构地区：[1]河北省血液中心,石家庄050071 [2]白求恩国际和平医院健康管理中心

出　　处：《医学动物防制》2013年第8期870-872,共3页Journal of Medical Pest Control

摘　　要：血红蛋白氧载体(hemoglobin-based oxygen carriers,HBOCs)已经研究出3代产品,每一代产品在血红蛋白抗氧化方面所采取的措施有明显的不同。本文结合国内外血红蛋白氧载体多年的研究,综述了3代血红蛋白氧载体在抗氧化、防止高铁血红蛋白(methemoglobin,MetHb)形成方面所采取的不同方法、作用机制和抗氧化效果。Three generations of hemoglobin based oxygen carriers （HBOCs） have been developed, and were respectively took different measures for anti - oxidation of hemoglobin. Based on research of HBOCs at home and abroad, this article reviews different measures, mechanism and effects of anti - oxidation for three genera- tions of HBOCs in anti - oxidation, which can prevent formation of methemoglobin.

关 键 词：血红蛋白氧载体 抗氧化 高铁血红蛋白 

分 类 号：R331.141[医药卫生—人体生理学]