Pulse Wave Analysis in Patients with Coronary Heart Disease Based on Hilbert-Huang Transformation and Time-domain  

作　　者：LI Fu-feng WANG Yi-qin SUN Ren XUE Song YAO Di SHEN Hai-dong 

机构地区：[1]Syndrome Laboratory of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine [2]Department of Engineering Mechanics, Shanghai Jiao Tong University [3]Department of Cardio-thoracic Surgery of Renji Hospital Affiliated to Medicine School of Shanghai Jiao Tong University

出　　处：《Chinese Journal of Biomedical Engineering(English Edition)》2013年第2期47-54,共8页中国生物医学工程学报（英文版）

基　　金：The National Basic Research Program (973 Program);grant number: 2003CB517108

摘　　要：Objective: To study the characteristics of pulse tracings in CHD, and objectively evaluate the significance of pulse signal in diagnosis and appreciation of therapeutic effect in patients with coronary heart disease(CHD), and accordingly provide with theoretic proofs for developing non-invasive technique of pulse diagnosis. Methods: By using the pulse detection system, pulse graphs in CHD patients, patients without CHD and "health" adults were collected and compared. Then characters of the pulse signal were analyzed with Hilbert-Huang transformation routine (HHT) and time-domain method respectively. Results: There existed characteristic change in pulse graph in CHD. ① h1,h3,h4,h3/h1,t,t5/t4 in time domain parameters of pulse graph increased and w1 was widened. ② 44% of C2 wave in HHT display showed chaotic and disorderly wave and irregularly wave amplitude in CHD. And 72% of C5 Wave exhibited in irregular wave with average wave amplitude over 10 gram-forces. These changes were significantly different from health adults. Conclusion: Characteristic wave of pulse graph extracted with methods of time domain or HHT routine might be considered as proofs for diagnosis and differentiation in CHD. Our researches prognosticate that pulse diagnosis can be used as an ancillary determination in occurrence of CHD for reasons of the advantage of convenient operation and non-invasion.Objective： To study the characteristics of pulse tracings in CHD, and objectively evaluate the significance of pulse signal in diagnosis and appreciation of therapeutic effect in patients with coronary heart disease（CHD）, and accordingly provide with theoretic proofs for developing non-invasive technique of pulse diagnosis. Methods： By using the pulse detection system, pulse graphs in CHD patients, patients without CHD and ＂health＂ adults were collected and compared. Then characters of the pulse signal were analyzed with Hilbert-Huang transformation routine （HHT） and time- domain method respectively. Results： There existed characteristic change in pulse graph in CHD. ①h1,h3,h4,h3/h1,t,tS/t4 in time domain parameters of pulse graph increased and wl was widened. ② 44% of C2wave in HHT display showed chaotic and disorderly wave and irregularly wave amplitude in CHD. And 72% of C5 Wave exhibited in irregular wave with average wave amplitude over 10 gram-forces. These changes were significantly different from health adults. Conclusion： Characteristic wave of pulse graph extracted with methods of time domain or HHT routine might be considered as proofs for diagnosis and differentiation in CHD. Our researches prognosticate that pulse diagnosis can be used as an ancillary determination in occurrence of CHD for reasons of the advantage of convenient operation and non-invasion.

关 键 词：coronary heart disease(CHD) pulse graph Hilbert-Huang transformation(HHT) time-domain method 

分 类 号：R318.08[医药卫生—生物医学工程]