清热泻火和解痉镇痛中药对吗啡依赖大鼠脑和脾组织内μ阿片受体含量的影响  

Influence of Chinese Herb Effective to Clear Heat and Fire,and Stop Spasm and Pain on the Content of μ Opium Receptor in Brain and Spleen of Morphine dependent Rats

作　　者：胡军[1] 莫启忠[1] 宫斌[1] 马骏[1] 陆英[1] 辛玉虎[1] 李瑾[1] 

机构地区：[1]上海中医药大学,上海200032

出　　处：《上海中医药杂志》2000年第8期42-44,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目! (970 0 1 89) ;上海市教育发展基金会曙光计划资助项目! (97SG31 )

摘　　要：利用吗啡成瘾大鼠模型观察清热泻火和解痉镇痛中药对脊髓、丘脑、大脑皮层以及脾组织中 μ型阿片受体含量的影响。实验证实 :吗啡成瘾大鼠除丘脑外 ,在大脑皮层、脊髓、脾组织中的μ型阿片受体含量均较正常大鼠显著下降 (P <0 0 5～ 0 0 0 1 ) ,中药对下降的 μ型阿片受体含量有明显上调作用 (P <0 0 5～ 0 0 1 )。认为阿片受体激动剂可能导致大脑皮层、脊髓组织细胞膜上的 μ型阿片受体脱敏 ,受体与G蛋白解除偶联 ,从而失去传导信息的作用 ,而清热泻火和解痉镇痛中药可以一定程度地调节 μ型阿片受体的敏感性 。The influence of Chinese herb effective to clear heat and fire,and stop spasm and pain on the content of μ-opium receptor in spinal cord,thalamus,cerebral cortex and spleen of morphine-addictive rats was observed.The experiment demonstrated that the content of μ-opium receptor in cerebral cortex,spinal cord and spleen was remarkably lower in morphine-addictive rats than that in normal rats ( P <0 05～0 001) and the Chinese herb could obviously increase the content of μ-opium receptor ( P <0 05～0 001).It was inferred that excitant of μ-opium receptor could lead to desensitization of μ-opium receptor on cytomembrane in cerebral cortex and spinal cord,and decoupling of receptor and G protein,consequently it failed to conduct the information;while Chinese herb effective to clear heat and fire,and stop spasm and pain could regulate the sensitivity of μ-opium receptor at some degrees and then exerted its detoxifying effects.

关 键 词：清热泻火 解痉镇痛 吗啡依赖 大鼠 中医药疗法 

分 类 号：R285[医药卫生—中药学]