抑肝健脾复方抗Wistar大鼠肝纤维化的研究  

EXPERIMENTAL STUDY OF YDGANJIANPI FANG ANTI-HEPATIC FIBROGENESIS IN THE RATS

作　　者：王树槐[1] 龙爱华[1] 朱虹[1] 徐立春[1] 陈瑾[1] 

机构地区：[1]扬州大学医学院,扬州225001

出　　处：《江苏临床医学杂志》2000年第1期22-24,共3页Journal of Jiangsu Clinical Medicine

基　　金：江苏省科委资助项目

摘　　要：目的 :研究抑肝健脾复方预防和治疗肝纤维化的作用。方法 :采用 40 %CCl4制备大鼠肝纤维化模型 ,以秋水仙碱为对照 ,观察抑肝健脾复方对大鼠肝纤维化各项指标的影响。结果 :抑肝健脾复方能显著降低大鼠血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶 (AST)、透明质酸 (HA)和肝组织中羟脯氨酸 (HyP)的水平 ,并能显著减轻肝脏胶原纤维增生程度。结论Objective:The aim of this study was to inquire into the effects of YeganJianpi Fang on anti-hepatic fibrosis.Methods:27 adult Wistar rats were randomly divided into 5 groups: heathly control group, CCl 4 injured rats left untreated (CCl 4 group), and CCl 4 injured rats treated with YeganJianpi Fang (low group, high group) and CCl 4 injured rats treated with colchicine as control ( colchicine control group). Liver fibrosis was induced in rats by subcutaneous injection of 40% CCl 4 oily solution, low group and high group were treated with YeganJianpi Fang. After 8-week treatment, rats were killed and the following parameters of hepatic fibrosis was determined: Serum alanine minotransferase (ALT), aspartate aminotransferase (AST) , hyaturonic acid (HA), hydroxyprocinine (HyP) level of hepatictissues. Results: The results indicated the levels of serum ALT, AST, HA in rats of YeganJianpi Fang (high group) was significantly lower than that of the CCl 4 group (P<0.05). In hepatic tissue, the hydroxyprocinine was significantly lower too. Conclusion:The YeganJianpi Fang has inhibitory effects on hepatofibrosis.

关 键 词：抑肝健脾方 肝纤维化 胶原 中医药疗法 大鼠 

分 类 号：R259.752[医药卫生—中西医结合]