Trichloroethylene Induces Biphasic Concentration-dependent Changes in Cell Proliferation and the Expression of SET-Associated Proteins in Human Hepatic L-02 Cells  

作　　者：HONG Wen Xu YE Jin Bo CHEN Mou Tong YAN Yan ZHOU Gui Feng YANG Xi Fei YANG Liang REN Xiao Hu HUANG Hai Yan ZHOU Li HUANG Xin Feng ZHUANG Zhi Xiong LIU Jian Jun 

机构地区：[1]Key Laboratory of Modern Toxicology of Shenzhen, Medical Key Laboratory of Guangdong Province, Medical Key Laboratory of Health Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention [2]Medical College, Hunan Normal University [3]Shenzhen Nanshan Center for Disease Control and Prevention

出　　处：《Biomedical and Environmental Sciences》2013年第7期618-621,共4页生物医学与环境科学（英文版）

基　　金：supported by NSFC (the National Natural Science Foundation of China) [81273126, 30972454];the Key Project of Guangdong Natural Science Foundation [S2012020010903];the Project of Shenzhen Basic Research Plan [JCYJ20120616 154222545];the Upgrade Scheme of Shenzhen Municipal Key Laboratory [CXB201005260068A];Medical Scientific Research Foundation of Guangdong Province (A2012577)

摘　　要：Trichloroethylene （TCE） is a major pollutant that affects both occupational and general environments. The liver is an important target organ of TCEE. Substantial efforts and remarkable progress into understanding TCE cytotoxicity have been made in cultured liver cells. However, the molecular mechanisms by which TCE induces hepatotoxicity are not well understood. SET （also known as protein phosphatase 2A inhibitor, 12PP2A, or template-activating factor-I, TAF-D is a nuclear protein that regulates histone modification, gene transcription, DNA replication, nucleosome assembly,Trichloroethylene （TCE） is a major pollutant that affects both occupational and general environments. The liver is an important target organ of TCEE. Substantial efforts and remarkable progress into understanding TCE cytotoxicity have been made in cultured liver cells. However, the molecular mechanisms by which TCE induces hepatotoxicity are not well understood. SET （also known as protein phosphatase 2A inhibitor, 12PP2A, or template-activating factor-I, TAF-D is a nuclear protein that regulates histone modification, gene transcription, DNA replication, nucleosome assembly,

关 键 词：SET As TCE Trichloroethylene Induces Biphasic Concentration-dependent Changes in Cell Proliferation and the Expression of SET-Associated Proteins in Human Hepatic L-02 Cells 

分 类 号：R114[医药卫生—卫生毒理学]