兰州地区供血员、静脉毒瘾者和肝炎患者血清输血传播病毒检测及致病性研究  

Study on transfusion transmitted virus infection and its pathogenicity in blood donors,intravenous drug-abusers and patients with liver diseases in Lanzhou area

作　　者：焦建中[1] 刘旺国[1] 李爱月[1] 焦建新[1] 邱瑛锋[1] 

机构地区：[1]解放军第一医院,甘肃兰州730030

出　　处：《西北国防医学杂志》2000年第3期181-183,共3页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的 :研究兰州地区供血员、静脉毒瘾者和肝病患者中输血传播病毒 (TTV)的感染状况及致病性。方法 :采用套式PCR技术检测 12 0例供血员、5 6例静脉毒瘾者和 74例肝病患者血清中TTV -DNA。结果 :TTV -DNA检出率供血员为 7.5 % (9/12 0 ) ,静脉毒瘾者为 2 6 .8% (15 / 5 6 ) ,肝病患者为 13 .4% (10 / 74)。 10例TTV -DNA阳性的肝病患者中 ,6例为单一TTV感染 ,1例与甲型肝炎病毒重叠感染 ,2例与乙型肝炎病毒重叠感染 ,1例为乙、庚型肝炎病毒和TTV重叠感染。 10例TTV感染者中 4例ALT增高 ,3例呈急性肝炎的临床症状。结论 :TTV感染可经血液和胃肠道传播 ,多呈病毒携带状态 ,也可单独引起急性肝炎 ,但致病性较弱。Objective:To study the infection rate and pathogenicity of transfusion transmitted virus(TTV) among blood donors,intravenous drug-abusers and patients with liver diseases in Lanzhou area.[WT5HZ]Methods:TTV-DNA was detected from sera of 120 blood donors,56 intravenous drug-abusers and 74 patients of liver diseases by nested-PCR technique.[WT5HZ]Results:TTV-DNA was detected in 9/120(7.5%) blood donors,15/56(26.8%) intravenous drug-abusers and 10/74(13.4%) patients with liver diseases.Among 10 TTV infected patients,there were 6 with simple TTV infection,1 with HAV and TTV co-infection,2 with HBV and TTV co-infection,1 with HBV,HGV and TTV co-infection.Also among these 10 patients,3 were associated with elevated aminotransferase,3 presented clinical symptoms of acute hepatitis.[WT5HZ]Conclusion:TTV infection can be transmitted through blood or gastrointestinal way,but its pathogenicity is mild.Futher studies should be done to explor its etiology,epidermiology and clinical significance. [WT5HZ]

关 键 词：TTV 肝炎 供血员 静脉毒瘾者 

分 类 号：R446.1[医药卫生—诊断学]