Design,synthesis and insecticidal activity of novel anthranilic diamides with benzyl sulfide scaffold  

作　　者：Yin-Bo Chen Ji-Ling Li Xu-Sheng Shao Xiao-Yong Xu Zhong Li 

机构地区：[1]Shanghai Key Lab of Chemistry Biology,School of Pharmacy,East China University of Science and Technology

出　　处：《Chinese Chemical Letters》2013年第8期673-676,共4页中国化学快报（英文版）

基　　金：supported by National Basic Research Program of China(973 Program,No.2010CB126100);National High Technology Research and Development Program of China (863 Program,No.2011AA10A207);supported by National Key Technology R&D Program of China(No. 2011BAE06B01)

摘　　要：A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized,in which N-pyridylpyrazole moiety generally regarded as key pharmacophore was abandoned.The target compounds were characterized by ~1H NMR,^（13）C NMR,^（19）F NMR and HRMS.The preliminary bioassays indicated that half of the title compounds were endowed with good insecticidal activities against armyworm（Mythimna sepatara） at the concentration of 500 mg/L,Exhilaratingly,the synthesized compound 3a was also active against Tetranychus cinnabarinus at 100 mg/L.The difference in activities between the target compounds was influenced by the substituents,which provided some hints for further investigation on structure modifications.A series of novel anthranilic diamides with benzyl sulfide scaffold were synthesized,in which N-pyridylpyrazole moiety generally regarded as key pharmacophore was abandoned.The target compounds were characterized by ~1H NMR,^（13）C NMR,^（19）F NMR and HRMS.The preliminary bioassays indicated that half of the title compounds were endowed with good insecticidal activities against armyworm（Mythimna sepatara） at the concentration of 500 mg/L,Exhilaratingly,the synthesized compound 3a was also active against Tetranychus cinnabarinus at 100 mg/L.The difference in activities between the target compounds was influenced by the substituents,which provided some hints for further investigation on structure modifications.

关 键 词：Anthranilic diamides Benzyl sulfide Synthesis Insecticidal activity 

分 类 号：TQ453.2[化学工程—农药化工]