An efficient synthesis of substituted 1,4-diazepines by a Pd catalyzed amination and sequential hydrogenation condensation  

作　　者：Xiao-Jian Wang Yu-Lin Tian Qing-Yang Zhang Jian-Guo Qi Da-Li Yin 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation,Institute of Materia Medica,Peking Union Medical College and Chinese Academy of Medical Sciences

出　　处：《Chinese Chemical Letters》2013年第8期743-746,共4页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation of China(No.81102322)

摘　　要：An efficient synthesis of substituted 1,4-diazepines is developed.The accessible intermediates have been obtained via Pd-catalyzed amination.The subsequent hydrogenation and intramolecular condensation sequences could be conducted successively in one pot without special operation.The mild and general strategy enables the synthesis of various substituted 1,4-diazepines in high yields.An efficient synthesis of substituted 1,4-diazepines is developed.The accessible intermediates have been obtained via Pd-catalyzed amination.The subsequent hydrogenation and intramolecular condensation sequences could be conducted successively in one pot without special operation.The mild and general strategy enables the synthesis of various substituted 1,4-diazepines in high yields.

关 键 词：1 4-Diazepines Pd-catalyzed amination Hydrogenation Intramolecular condensation 

分 类 号：O643.32[理学—物理化学]