不完全性急性脊髓损伤后脊髓病理改变、脊髓灰质血流量和运动诱发电位变化的实验研究  

Study of the changes of spinal cord histopathology, grey matter blood flow and motor-evoked potential after acute incomplete paraplegia in rabbits

作　　者：初同伟[1] 吴梅英[2] 马树支[2] 王大勇[2] 

机构地区：[1]第三军医大学:附属新桥医院骨科,重庆400037 [2]第三军医大学附属西南医院骨科,重庆400038

出　　处：《第三军医大学学报》2000年第8期750-753,共4页Journal of Third Military Medical University

摘　　要：目的　观察不完全性急性脊髓损伤后脊髓病理改变、灰质血流量、运动诱发电位及运动功能的变化规律及其相互间的关系。方法　应用过邦辅的脊髓腹侧损伤模型造成兔不完全性急性脊髓损伤 ,在不同时相点测定动物运动功能、运动诱发电位、伤部脊髓血流量及观察光镜电镜变化。结果　不完全性急性脊髓损伤后血流量在伤后 6h降低至最低点 ,以后逐渐恢复。运动诱发电位变化和脊髓血流量变化趋势相同 ,随着脊髓血流量及病理改变的恢复 ,运动诱发电位及脊髓运动功能逐渐好转。结论　急性脊髓损伤后伤部脊髓血流量、运动功能、运动诱发电位和其病理变化呈一致性。Objective To study the changes of spinal cord histopathology, local blood flow of the grey matter, motor evoked potential and motor function after acute incomplete paraplegia in rabbits. Methods Rabbit model of incomplete paraplegia was established with the anterior spinal cord impingement method of Guo Bangfu. Then the changes of the blood flow of the grey matter, motor evoked potential and motor function of the animals were observed and the histopathological changes of the damaged cord tissues were studied with light and electron microscopy after the animals were killed at different time points after injury. Results The blood flow of the grey matter was decreased to the lowest point in the 6th hour after injury and then recovered gradually. The motor evoked potential showed similar changes to the blood flow of the grey matter. Motor evoked potential and motor function of the animals gradually restored their normal level along with the recovery of blood flow and pathological changes of the spinal cord. Conclusion Local blood flow of the grey matter, motor function and motor evoked potential after acute incomplete paraplegia is consistent with the changes of spinal cord histopathology.

关 键 词：急性脊髓损伤 脊髓灰质血流量 运动诱发电位 

分 类 号：R651.202[医药卫生—外科学]