循环microRNA、微球蛋白与急性心肌梗死的相关性分析  

Correction between circulating microRNA,microglobulin and acute myocardial infarction

作　　者：朱继荣[1] 杨俊芬[1] 卢章[1] 庄义浩[1] 倪素丹[1] 李文静[1] 

机构地区：[1]深圳市第二人民医院心内科,广东深圳518000

出　　处：《海南医学院学报》2013年第10期1406-1408,共3页Journal of Hainan Medical University

基　　金：深圳市科技计划项目(201102063)~~

摘　　要：目的:探讨分析循环microRNA、微球蛋白与急性心肌梗死的相关性。方法:选取2012年7月～2013年2月于本院进行诊治的54例急性心肌梗死患者为观察组,同时期体检的54例健康人员为对照组,比较两组人员及观察组不同Killip分级患者的循环microRNA、微球蛋白水平,并分析上述指标与急性心肌梗死的相关性。结果:观察组的α1-微球蛋白(α1-MG)、β2-微球蛋白(β2-MG)、microRNA-499、microRNA-214及microRNA-208均高于对照组,microRNA-21低于对照组,且观察组Killip分级高者波动大于分级低者,差异均有统计学意义(P均<0.05);上述指标均与急性心肌梗死有密切的相关性。结论:急性心肌梗死患者的循环microRNA与微球蛋白呈现异常状态,且不同Killip分级者存在明显的差异,其与急性心肌梗死有明显的相关性。Objective：To study the correction between circulating microRNA,microglobulin and acute myocardial infarction.Methods：A total of 54patients with acute myocardial infarction admitted from July 2012to February 2013were selected as observation group,54healthy persons with health examination at the same time were selected as control group.The circulating microRNA and microglobulin levels were observed and compared,and the correction between those indexes and acute myocardial infarction was analyzed.Results：α1-MG,β2-MG,microRNA-499,microRNA-214and microRNA-208of observation group were all higher than those of control group,microRNA-21was lower than that of control group,those indexes fluctuations of observation group with higher Killip grade were larger than those with lower Killip grade（all P0.05）.Those indexes all had closely correlation with acute myocardial infarction.Conclusion： Patients with acute myocardial infarction had abnormal circulating microRNA and microglobulin,and those indexes were different in patients with different Killip grade.They have closely correlation with acute myocardial infarction.

关 键 词：循环MICRORNA 微球蛋白 急性心肌梗死 相关性 

分 类 号：R542.22[医药卫生—心血管疾病]