普罗布考联合辛伐他汀对颈动脉粥样硬化斑块作用的临床研究  

Therapeutic effect of probucol and simvastatin in treating carotid atherosclerosis plaque

作　　者：汪波[1] 张香三 符国平[1] 陈志丘 

机构地区：[1]海南省农垦三亚医院,海南三亚572000

出　　处：《海南医学院学报》2013年第10期1409-1411,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210812)~~

摘　　要：目的:探讨普罗布考联合辛伐他汀对颈动脉粥样硬化斑块的影响及作用。方法:入选180例首次确诊颈动脉粥样硬化斑块患者,随机分为联合治疗组(普罗布考500mg/d,辛伐他汀20mg/d)和单药治疗组(辛伐他汀20mg/d),共观察24周。分别于治疗前后检测两组血脂水平,并用彩色多普勒超声检测颈动脉内中层厚度、颈动脉内膜粥样斑块面积。结果:治疗24周后,两组治疗前后对血脂水平和颈动脉粥样斑块内中膜厚度以及斑块面积均有改善明显,无严重不良反应;联合治疗组对于血脂水平和内中膜厚度以及斑块面积的改善程度较单药治疗组更明显。结论:普罗布考联合辛伐他汀对血脂及颈动脉粥样硬化治疗作用明显,安全性高。Objective：To evaluate the therapeutic effect of probucol and simvastatin in treating carotid atherosclerosis plaque.Methods：One hundred and eighty patients with carotid atherosclerosis were divided randomly into simvastatin group（n=18）and combination group（n=18）.The therapeutic effects were evaluated by arteria carotis IMT and the size of carotid atherosclerosis plaque was measured by color Dopplar.Results：After 24week of treatment,the simvastatin group and the combination group showed reductions in TG,TC,LDL,arteria carotis IMT and the size of carotid atherosclerosis plaque.The combination group showed more significant efficacy compared with simvastatin group.Conclusion：Combined therapy of probucol and simvastatin is effective and safe for treating carotid atherosclerosis.

关 键 词：动脉粥样硬化 普罗布考 辛伐他汀 血脂 

分 类 号：R543[医药卫生—心血管疾病]