A novel human coronavirus:Middle East respiratory syndrome human coronavirus  

作　　者：GENG HeYuan TAN WenJie 

机构地区：[1]Biotech Center for Viral Disease Emergency,Key Laboratory of Medical Virology and Viral Diseases Prevention and Control,Ministry of Health,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention

出　　处：《Science China(Life Sciences)》2013年第8期683-687,共5页中国科学（生命科学英文版）

基　　金：supported by grants from the National Basic Research Program of China (2011CB504704);the State Megaproject for Infectious Disease Research of China (2011ZX10004-001)

摘　　要：In 2012,a novel coronavirus,initially named as human coronavirus EMC(HCoV-EMC) but recently renamed as Middle East respiratory syndrome human coronavirus(MERS-CoV),was identified in patients who suffered severe acute respiratory infection and subsequent renal failure that resulted in death.Ongoing epidemiological investigations together with retrospective studies have found 61 laboratory-confirmed cases of infection with this novel coronavirus,including 34 deaths to date.This novel coronavirus is culturable and two complete genome sequences are now available.Furthermore,molecular detection and indirect immunofluorescence assay have been developed.The present paper summarises the limited recent advances of this novel human coronavirus,including its discovery,genomic characterisation and detection.In 2012, a novel coronavirus, initially named as human coronavirus EMC （HCoV-EMC） but recently renamed as Middle East respiratory syndrome human coronavirus （MERS-CoV）, was identified in patients who suffered severe acute respiratory infec- tion and subsequent renal failure that resulted in death. Ongoing epidemiological investigations together with retrospective studies have found 61 laboratory-confirmed cases of infection with this novel coronavirus, including 34 deaths to date. This novel coronavirus is culturable and two complete genome sequences are now available. Furthermore, molecular detection and indirect immunofluorescence assay have been developed. The present paper summarises the limited recent advances of this novel human coronavirus, including its discovery, genomic characterisation and detection.

关 键 词：HCoV-EMC MERS-CoV genomic characterisation molecular detection 

分 类 号：R373[医药卫生—病原生物学]