肥胖与雌激素的相互关系及其对子宫的作用研究  

The relationship of obesity and estrogen and their impact on uterus

作　　者：张媛媛[1] 张日华[1] 薛一[1] 刘梦兰[1] 黄琼[1] 刘云[1] 

机构地区：[1]南京医科大学第一附属医院老年医学科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2013年第8期1060-1065,共6页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金资助(81070684);江苏省科技支撑项目(BE2011802);上海市糖尿病重点实验室开放课题资助(SHKLD-KF-1105);南京医科大学第一附属医院创新团队工程

摘　　要：目的:探讨肥胖与雌激素的相互关系及对子宫的影响。方法:将48只SD大鼠随机分为6组:普通饮食组(A组)、高脂饮食组(B组)、去势后普通饮食组(C组)、去势后高脂饮食组(D组)、去势后雌激素替代普通饮食组(E组)、去势后雌激素替代高脂饮食组(F组)。每周检测体重,饲养14周后,进行腹腔注射葡萄糖耐量试验(IPGTT实验);16周后处死实验大鼠,取血清测量生化指标并比较各组大鼠的子宫直观表象及组织学改变。结果:缺乏雌激素会导致实验大鼠体重及内脏脂肪含量的增加。甘油三酯(TG)、血糖(GLU)、尿酸(UA)水平与雌激素水平负相关,TG水平与肥胖正相关,但各组指标差异不显著。雌激素缺乏与胰岛素抵抗有关,雌激素替代能够增加胰岛素敏感性并降低血糖。雌激素撤退会导致子宫萎缩,而给予替代雌激素后能明显促进子宫的生长发育。雌激素、肥胖与子宫内膜的增殖均为正相关关系。结论:雌激素与肥胖密切相关,两者均与子宫的生长发育和子宫内膜的增殖正相关。Objective：To investigate the relationship between obesity and estrogen and their impact on uterus.Methods：Totally 48 rats were randomly divided into the following six groups：normal diet group（A）,the high-fat diet group（B）,uterectomy and normal diet group（C）,uterectomy and high-fat diet group（D）,estrogen supplement and normal diet group（E）,estrogen supplement and high-fat diet group（F）.The weight of the SD rats was tested weekly.The IPGTT experiment were taken after 14 weeks,and the experiment rats were executed after 16 weeks.The biochemical indicators were measured and the appearance of the uterus and the histological changes of different groups of the rats were compared.Results：Lack of estrogen increased the body weight and visceral fat content.TG,GLU,UA levels were negatively correlated with the estrogen level,while TG level was positively correlated with obesity.But there was no significant differences among these groups.The deficience of estrogen was associated with the insulin resistance,and the replacement of estrogen elevated insulin sensitivity and reduced blood glucose.The absence of estrogen led to analosis of uterus,and estrogen supplement significantly promoted the growth and development of uterus.Estrogen and obesity are both positively correlated with endometrial proliferation.Conclusion：Estrogen is closely correlated with obesity,and they both positively related to the growth and development of uterus and endometrial proliferation.

关 键 词：肥胖 雌激素 子宫 

分 类 号：R723.14[医药卫生—儿科]