乙型肝炎病毒对乙肝患者血脂水平的影响及其临床意义探讨  

Effects of different load of hepatitis B virus on the serum lipids in chronic hepatitis B patients

作　　者：高鹏[1] 肖萍[1] 杨彦麟[1] 赵桂玲[2] 何强[1] 魏喜生[1] 王立明[1] 周萍[1] 陈青锋[1] 周伟[1] 

机构地区：[1]兰州大学第一医院传染病研究室,甘肃兰州730000 [2]兰州大学第一医院肾病科,甘肃兰州730000

出　　处：《南京医科大学学报（自然科学版）》2013年第8期1122-1125,共4页Journal of Nanjing Medical University(Natural Sciences)

摘　　要：目的:评价不同载量的乙型肝炎病毒对乙肝患者血脂水平的影响。方法:采用全自动生化分析仪检测412例慢性乙型肝炎患者的肝功、肾功、血脂、血糖等指标,采用荧光定量PCR检测被测者的病毒载量,采用全自动血凝仪检测血浆凝血酶原活动度(PTA)。结果:协方差分析提示在轻度、中度、重度慢性乙型肝炎组中,不同病毒载量的乙型肝炎病毒对血脂水平[胆固醇(CHOL)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]无影响或影响甚微。在慢性重型肝炎组中,不同载量的乙型肝炎病毒对血脂水平有明显影响。同时多元线性回归分析显示重型肝炎组中血脂水平主要受病毒载量(lgDNA)、PTA、白蛋白(ALB)等的影响。结论:不同载量的乙型肝炎病毒对血脂水平的影响在各个病变阶段是不同的,通过动态观察血脂水平和病毒载量,可以了解机体的免疫状况以及乙型肝炎病毒在机体病理性免疫反应中所发挥的作用。Objective：To evaluate the effect of different load of hepatitis B virus on the serum lipids in chronic hepatitis B patients.Methods：The liver function parameters,the renal function parameters and the serum glucose of 412 hepatitis B patients were m easured by automatic biochemical analyzer,the hepatitis B virus load were measured by quantitative PCR and the plasma prothrombin activity（PTA） were detected by automatic coagulometer.Results：The covariance analysis suggested that hepatitis B virus has no effect on the serum lipids（cholesterol,triglycerides,high-density lipoprotein cholesterol,low-density lipoprotein cholesterol） or the effect is negligible in the mild,moderate,severe chronic hepatitis B patients groups.While in the hepatic failure group,the hepatitis B virus has a significant effect on the serum lipids.The multiple linear regression analysis showed that the serum lipids in the hepatic failure group was mostly affected by the viral load（lgDNA）,PTA,albumin.Conclusion：The different load of hepatitis B virus had different effect on the serum lipids in different stage of chronic hepatitis B patients.Through dynamic observation of lipid levels and viral load,we can understand the body immune status,as well as the role of hepatitis B virus in the body pathological immune response.

关 键 词：慢性乙型肝炎 血脂 病毒载量 免疫 

分 类 号：R512.6[医药卫生—内科学]