健脾增敏汤改善2型糖尿病胰岛素抵抗的临床研究  

Clinical Study on Effect of Jian-pi Zeng-min Decoction for Insulin Resistance in Type 2 Diabetes Mellitus

作　　者：彭俊杰[1] 叶仁群[1] 黄寅銮[1] 宋银枝[1] 宋群利[1] 迟林园[1] 

机构地区：[1]深圳市宝安区中医院,广东深圳518133

出　　处：《中医药导报》2013年第7期24-26,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：深圳市科技计划项目(201203271);深圳市宝安区科技计划项目(2012043)

摘　　要：目的:观察健脾增敏汤对2型糖尿病胰岛素抵抗(IR)患者血清抵抗素、肿瘤坏死因子-α(TNF-α)的影响。方法:将80例2型糖尿病胰岛素抵抗患者随机分为治疗组和对照组各40例。治疗组在基础治疗同时加用健脾增敏汤,对照组在基础治疗同时加服盐酸二甲双胍。治疗8周后观察患者治疗前后血清抵抗素、TNF-α水平的变化。结果:治疗后治疗组患者的血清抵抗素、TNF-α明显低于对照组,差异有统计学意义(P<0.05);总有效率治疗组为92.5%,对照组为77.5%,治疗组优于对照组,差异有统计学意义(P<0.05)。结论:健脾增敏汤能改善2型糖尿病胰岛素抵抗患者的胰岛素抵抗,其作用机制可能与降低患者血清抵抗素和TNF-α的水平有关。Objective： To evaluate the effect of Jian-pi Zeng-min decoction on the serum resistin and tumor necrosis fac tor-α（TNF-α） in Resistance to insulin of Type 2 diabetes（IR）.Methods： 80 cases of patients with insulin resistance of Type 2 diabetes were randomly divided into treatment and control group,40 cases in each group.Patients were treated with basic treatment plus Jian-pi Zeng-min decoction in treatment group,and basic treatment plus oral metformin hydrochloride in control group.The changes of serum resistin and TNF-α levels were measured before and after treatment,in 8 weeks.Results： The level of serum resistin and TNF-α in the treatment group was significantly lower than that of the control group,the difference was significant（P0.05）;The total effective rate was 92.5% and 77.5% respectively in treatment and control group.The clinical efficacy in the treatment group was better than that in the control group,with significant difference（P0.05）.Conclusion： Jian-pi Zeng-min decoction can relieve the insulin resistance of Type 2 diabetes,the mechanism of which may be related to the decrease of serum resistin and TNF-α.

关 键 词：健脾增敏汤 2型糖尿病 TNF-Α 血清抵抗素 

分 类 号：R255.4[医药卫生—中医内科学]