自身免疫性疾病患者红细胞体积分布宽度变化的研究  

Study on the change of red blood cell volume distribution width in patients with autoimmune diseases

作　　者：单娜[1] 张英辉[1] 王静[1] 孟冬娅[1] 郭大文[1] 

机构地区：[1]沈阳军区总医院检验科,沈阳110016

出　　处：《国际检验医学杂志》2013年第14期1807-1808,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨红细胞体积分布宽度(RDW)在自身免疫性疾病(AID)的变化及临床意义。方法选取126例AID患者及100例健康人为研究对象。采用全自动血液分析仪测定红细胞体积分布宽度(RDW),间接免疫荧光法测定抗核抗体(antinu-clear antibody,ANA),速率散射比浊法测定C反应蛋白(C-reactive protein,CRP)。结果 AID患者RDW检测结果显著高于对照组(P<0.01),ANA高滴度组与低滴度组的RDW水平和阳性率差异均无统计学意义(t=1.568,P>0.05;χ2=3.13,P>0.05),CRP与RDW呈正相关(r=0.32,P<0.05)。结论 AID患者RDW升高,可能与慢性炎症有关。Objective To investigate the change and clinical significance of RDW in patients with autoimmune diseses（AID）.Methods 126 patients with AID and 100 healthy people were selected.RDW was determined with automatic blood analyzer,ANA was detected by indirect immunofluorescence,and CRP was detected by rate nephelometry.Results The level of RDW in AID patients was significantly higher than that in control group（P0.01）.The level and positive rate of RDW in high titer ANA group was not significantly different with those in low titer ANA group（t=1.568,P0.05;χ2=3.13,P0.05）.The level of RDW showed significantly positive correlation with CRP（r=0.32,P0.05）.Conclusion AID patients had increased level of RDW,and the increase of RDW may related with clinica inflammation of AID.

关 键 词：红细胞指数 抗体 抗核 自身免疫疾病 C反应蛋白质 

分 类 号：R593.2[医药卫生—内科学]