杀精抗菌双功能抗菌肽的研究进展  

Research Progress of the Antimicrobial Peptides with Dualfunctionality of Spermicide and Microbicide

作　　者：张尉[1] 侯丽[2] 于和鸣[2] 

机构地区：[1]北京协和医学院研究生院,100005 [2]国家人口计生委科学技术研究所

出　　处：《国际生殖健康／计划生育杂志》2013年第4期261-263,266,共4页Journal of International Reproductive Health/Family Planning

摘　　要：抗菌肽(antimicrobial peptides)是广泛存在于生物体内的一类抵抗外源性病原微生物致病作用的防御性小分子多肽。抗菌肽拥有巨大的抗菌潜能和广泛的抗菌谱,以及安全、无毒副作用等特点,其中有些抗菌肽还展现了强有力的杀精避孕功能。综述Magainin,Dermaseptins,Nisin和Subtilosin 4种抗菌肽的杀精抗菌功能,为研制具有杀精抗菌双功能的生物制剂提供新的思路和来源。Antimicrobial peptides are of important components of low-molecular weight peptides to defense organisms invasion.Antimicrobial peptides have many characteristics,such as the big antibacterial potential,broad antibacterial spectrum,safety,and non-toxic.Some of them also have powerful spermicidal and contraceptive potential.This review introduced the difunctionality of spermicide and microbicide of four antimicrobial peptides,including Magainin,Dermaseptins,Nisin and Subtilosin,which could provide us new ideas to develop the biological products with the difunctionality of spermicide and microbicide.

关 键 词：抗菌药 肽类 杀精子药 避孕药 男用 综述 

分 类 号：R96[医药卫生—药理学]