痰热清注射液联合西吡氯胺含漱液预防卒中相关肺炎的临床研究  

Clinical Research of Stroke-Associated Pneumonia Prevented with Tanreqing Injection and Cetylpyridinium Chloride Gargle

作　　者：刘宇[1] 李洪[1] 刘红娟[1] 魏莉[1] 张媛媛[1] 

机构地区：[1]解放军第261医院,北京100094

出　　处：《世界中西医结合杂志》2013年第7期737-739,共3页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的探讨痰热清注射液合并西吡氯胺含漱液口腔护理对卒中相关肺炎(SPA)的预防作用。方法对236例SAP高危患者进行随机分组。痰热清组采用痰热清注射液20 mL稀释于0.9%氯化钠注射液250 mL中,静脉滴注,每日1次。西吡氯胺组应用西吡氯胺含漱液20 mL漱口,每日2次。联合用药组同时应用痰热清和西吡氯胺含漱液,剂量同前。干预期10 d,用药20 d后观察各组SPA的发病率。结果联合用药组、痰热清组、西吡氯胺组和对照组SPA发病率分别是11.9%、15.5%、19.0%和27.1%。与对照组相比,联合用药组显著降低SPA发病率(P<0.05),而痰热清组、西吡氯胺组和对照组相比,SPA发病率差异无统计学意义(P>0.05)。结论痰热清注射液联合西吡氯胺含漱液可有效地保护SPA高危患者。Objective To explore the preventive effect on stroke -associated pneumonia（SAP） with Tanreqing Injection and Cetylpyridinium Chloride Gargle. Methods Two hundred and thirty - six SAP high -risk patients were randomized into groups. In Tanreqing group, Tanreqing Injection 20ml was applied, dilu ted with 0.9% sodium chloride injection 250ml, for intravenous drop, once a day. In Cetylpyridinium Chloride group,Cetylpyridinium Chloride Gargle 20ml was administered, twice a day. In the combined medication group, Tanreqing Injection and Cetylpyridinium Chloride Gargle were administered together, at the same do ses. The intervention period was 10 days. The incidence of SAP was observed in each group 20 days after medication. Results The incidences of SAP were 11.9%, 15.5%, 19.0% and 27.1% in the combined medication group, Tanreqing group, Cetylpyridinium Chloride group and control group separately. Compared with the control group, the incidence of SAP was reduced significantly in the combined medication group （P 〈 0.05 ）. The differences in the incidence of SAP were not significant in comparison among Tanreqing group, Cetylpyridinium Chloride group and control group（ P 〉 0.05 ）. Conclusion The combined administration of Tanreqing Injection and Cetylpyridinium Chloride Gargle effectively protects the patients of high - risk SAP.

关 键 词：痰热清 西吡氯胺 卒中相关肺炎 

分 类 号：R285.6[医药卫生—中药学] R563.1[医药卫生—中医学]