丹参注射液对急性肺损伤的疗效与安全性  

Effects and safety of Danshen injection in the treatment of patients with acute lung injury

作　　者：史朝红[1,2] 张近波[1,2] 许国斌[1,2] 董美平[1,2] 朱金强[1,2] 鄢来超[1,2] 曹烈祥[1,2] 吴仙丹[1,2] 

机构地区：[1]温州医学院附属温岭医院 [2]温岭市第一人民医院EICU,浙江温岭317500

出　　处：《中国临床药理学杂志》2013年第7期501-502,共2页The Chinese Journal of Clinical Pharmacology

摘　　要：目的研究丹参注射液对急性肺损伤(ALI)的疗效与安全性。方法 80名急性肺损伤患者随机分为对照组和丹参组。对照组用常规治疗。在常规治疗的基础上,丹参组给予丹参注射液40 mL加入5%葡萄糖注射液250 mL静脉滴注,每日1次,6 d为1个疗程。对2组患者的住院时间、肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)及药物不良反应(ADRS)等进行比较。结果丹参组比对照组住院时间明显缩短,ARDS发生率和病死率明显降低(均P<0.05)。治疗后第2,4,6 d,丹参组TNF-α水平、IL-1水平均较对照组明显降低(均P<0.05);结论丹参注射液可以抑制ALI患者TNF-α、IL-1水平,从而对ALI患者起到治疗作用。Objective To explore effects and safety of Danshen injection in the treatment of patients with acute lung injury（ALI）.Methods Eighty patients with ALI were collected.The patients were divided into control group and Danshen group.The control group used conventional treatment.The Danshen group was added 40 mL Danshen injection and 5% glucose injection 250 mL,once a day,on this basis.The patients in both groups were treated for 6 d.The characters of clinical and the level of tumor necrosis factor-α（TNF-α）,interleukin-1（IL-1） were compared between the two groups.The hospitalization time,adverce drugs reactions（ARDS）,mortality were investigated.Results The hospitalization time,ARDS incidence and mortality were significantly lower in Danshen group than that in control group（all P 0.05）.The lever of TNF-α,IL-1 were significantly lower in Danshen group than that in control group at the time after treatment in day 2,4 and 6（all P 0.05）.Conclusion Danshen injection had effective and safety for the AKI patients.

关 键 词：急性肺损伤 肿瘤坏死因子-Α 白细胞介素-1 丹参注射液 

分 类 号：R563[医药卫生—呼吸系统] R285.6[医药卫生—内科学]