体外受精胚胎移植后5周与8周停止黄体支持对妊娠率的影响  

Effect of stopping luteal support on ongoing pregnancy rate at the time after embryo transplantation week 5 or 8 in vitro fertilization/intracytoplasmic sperm injection

作　　者：王春艳[1] 吕丽萍[1] 王宜令 王曙光[1] 徐艳 

机构地区：[1]枣庄市妇幼保健院生殖医学中心,山东枣庄277100 [2]滕州市第一职业高中,山东滕州277500

出　　处：《中国临床药理学杂志》2013年第7期503-505,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察体外受精胚胎移植后5,8周停止黄体支持对妊娠率的影响。方法 150例体外受精患者,胚胎移植后5周经阴道超声证实为宫内妊娠后,随机分为2组:移植后5,8周停用黄体支持组(5周组、8周组),比较2组持续的妊娠率、流产率和出血事件的发生次数。结果移植后5周第1次超声检测:2组间的妊娠率差异无统计学意义,当天2组孕酮水平相似,分别为(152±118),(170±121)ng·mL-1。在妊娠早期比较2组的流血事件,5周组更多[(19.0±2.4)vs(8.2±1.9),P<0.001]。单胎妊娠流产率在2组间相似(4.62%,6.25%)。结论体外受精可在胚胎移植后5周安全地撤退外源性黄体支持,其持续妊娠率与8周组相似。Objective To investigate the effect of stopping luteal support at week 5 versus week 8 on ongoing pregnancy rate after embryo transplantation in vitro fertilization（IVF）/intracytoplasmic sperm injection（ICSI）.Methods One hundred and fifty patients with a long gonadotropin releasing hormone（GnRH） agonist protocol and intrauterine pregnancy demonstrated by transvaginal ultrasound after IVF/ICSI.The patients were randomly divided into 2 groups according to the time of suspending luteal support.Group 5-week and group 8-week,luteal phase support was suspended at week 5 or week 8 after embryo transplantation,respectively.Then,ongoing pregnancy rate,miscarriage rate,and number of bleeding episodes were compared between two groups.Results No significant difference was observed in ongoing pregnancy rate after embryo transplantation week 5 among two groups.Progesterone levels were similar on the day of the first pregnancy ultrasound exam at week 5 after embryo transplantation [（152 ± 118） ng.mL-1 vs 170 ± 121） ng.mL-1].Significantly more bleeding episodes were observed in the first trimester in group 5-week（19.0 ± 2.4） than in group 8-week（8.2 ±1.9）（P 0.001）.Miscarriage rates among singleton pregnancies were similar in the 2 groups（4.62%,6.25%）.Conclusion Luteal support after IVF/ICSI can be safely withdrawn at week 5 after embryo transplantation.The ongoing pregnancy rate is similar to luteal support for 5 weeks or 8 weeks after embryo transplantation.

关 键 词：体外受精 胚胎移植 黄体支持 妊娠结局 妊娠率 

分 类 号：R714[医药卫生—妇产科学] R984[医药卫生—临床医学]