单用与联用对稽留流产患者米非司酮血浆、蜕膜组织浓度及流产结局的影响  

Effects of mifepristone alone and combination with anordrin on the mifepristone concentration and abortion outcome in plasma or decidual tissue of patients with missed abortion

作　　者：董瑞谦[1] 俆延华 郭瑞臣[2] 

机构地区：[1]济南市妇幼保健院,济南250001 [2]山东大学齐鲁医院临床药理研究所,济南250012

出　　处：《中国临床药理学杂志》2013年第7期506-508,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察米非司酮单用与联用对稽留流产患者血浆、蜕膜组织米非司酮浓度及流产结局的影响。方法 47例稽留流产患者随机分2组,分别口服单方或复方米非司酮片,用高效液相色谱法测定血浆和子宫蜕膜组织米非司酮浓度。记录流产效果、出血量和流产时间。结果血浆和蜕膜组织的米非司酮浓度,2组间差异有统计学意义(P<0.05)。平均流产时间和出血量,复方组明显低于单方组(P<0.05)。结论米非司酮剂量与血浆和蜕膜组织浓度呈正比;与双炔失碳酯合用可缩短流产时间,减少出血量。Objective To study the effects of mifepristone alone and combination with anordrin on the mifepristone concentrations and abortion outcomes in plasma or decidual tissue of patients with missed abortion.Methods Forty-seven missed abortion patients were included and treated with single mifepristone tablets（50 mg） or mifepristone（30 mg） plus anordrintablets（5 mg）,respectively.Venous blood and decidua were collected and mifepristone concentrations was determined by HPLC.The adverse events,effect of medical abortion,bleeding amount and abortion time of the two groups were evaluated.Results The mifepristone concentrations in plasma and decidual tissue have significant difference（P 0.05） between two groups.The adverse drugs reaction rates and abortion efficient were not statistically different（P 0.05）,but not average abortion time and bleeding amount（P 0.05）.Conclusion The doses of mifepristone were directly proportion with the plasma and decidua concentrations.The abortion time was shorted and the bleeding amount was reduced with combination compared with alone.

关 键 词：复方米非司酮 米非司酮 双炔失碳酯 高效液相色谱法 单用与联用 

分 类 号：R714.21[医药卫生—妇产科学] R984[医药卫生—临床医学]