平胃舒胶囊质量标准制定  

Establishment of Quality Standard of Pingweishu Capsules

作　　者：徐乃玉[1] 张诗超[1] 田甜[1] 杨淑敏[1] 刘江云[1] 郝丽莉[1] 方正 

机构地区：[1]苏州大学医学部药学院,江苏苏州215123 [2]贵州汇恒投资有限公司,贵阳550008

出　　处：《中国实验方剂学杂志》2013年第16期101-103,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：贵州省中药现代化计划重点项目(20095002);江苏省"大学生实践创新训练计划"项目(2012zd017)

摘　　要：目的:建立平胃舒胶囊的质量控制标准。方法:采用薄层色谱法对制剂中黄连和延胡索进行鉴别;采用高效液相色谱法测定制剂中盐酸小檗碱含量。结果:薄层色谱斑点清晰,分离度较好,专属性强。高效液相色谱法测定结果,盐酸小檗碱在0.368～3.680μg线性关系良好(r=0.999 8),平均加样回收率99.86%,RSD 1.46%。结论:该方法快速、灵敏、准确,可有效控制平胃舒胶囊的质量。Objective： To establish the quality standards of Pingweishu capsules. Method： Coptis chinensis and Corydalis Rhizoma were identified by TLC. The content of berberine hydrochloride was determined by RP-HPLC. Result： The spots in the TLC were fairly clear, and no interference was shown in the blank samples. Berberine hydrochloride showed a good linear relationship within a range of 0. 368-3.68 μg （ r = 0. 999 8）. The average rate of recovery was 99. 86% （RSD 1.46% ）. Conclusion： The method is a simple, rapid and accurate analysis assay, which could be used for quality control of Pingweishu capsules.

关 键 词：平胃舒胶囊 盐酸小檗碱 薄层色谱 高效液相色谱 

分 类 号：R284.1[医药卫生—中药学]