顶空气相色谱法测定当药提取物中大孔树脂残留物  

Determination of Macroporous Resin Residues in Extract of Swertia pseudochinensis by Headspace Gas Chromatography

作　　者：常增荣[1] 傅欣彤[1] 刘颖[1] 

机构地区：[1]北京市药品检验所,北京100035

出　　处：《中国实验方剂学杂志》2013年第16期153-155,共3页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:建立当药提取物中大孔树脂残留物的检测方法。方法:采用顶空气相色谱法测定当药提取物中大孔树脂残留物(正己烷、苯、甲苯、二甲苯、苯乙烯、二乙基苯及二乙烯苯)含量。结果:7种成分均获得较好的分离,且呈良好线性关系(r为0.994 0～0.999 7),平均回收率93.4%～98.4%,精密度RSD均<10%,3批样品中均未检测出7种树脂残留物。结论:该方法简便快速、准确、重复性好,可用于大孔树脂有机溶剂残留量的测定。Objective： To Establish a method for detecting residues of macroporous resin in extract of Swertia pseudochinensis. Method： Headspace-GC was used to determine the content of macroporous resin residues of n-hexane, benzene, methylbenzene, dimethylbenzene, phenylethylene, diethylenzene, divinylbenzene in extract of S. pseudochinensis. Result： All of seven residues were separated and good linear responses were obtained in the mass concentration with r between 0. 994 0 to 0. 999 7. The average recoveries of these 7 residues were in the range of 93.4%-98.4% with RSD 〈 10% , these 7 residues were not detected in three batches of samples. Conclusion： This analytical method was convenient and accurate with good repeatability, it could be used to determine organic solvents residues in macroporous resin.

关 键 词：大孔树脂残留物 当药提取物 顶空气相色谱法 标准加入法 

分 类 号：R284.1[医药卫生—中药学]