北柴胡不同炮制品疏肝利胆药效作用初探  

Preliminary Study on Soothing Liver and Choleretic Effects of Bupleurum chinense and its Processed Products

作　　者：赵晶丽[1] 高红梅[2] 

机构地区：[1]吉林工业职业技术学院,吉林吉林132013 [2]长春中医药大学,长春130117

出　　处：《中国实验方剂学杂志》2013年第16期235-238,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：吉林省教育厅课题项目(2010-75)

摘　　要：目的:探讨不同炮制方法对北柴胡疏肝利胆药效作用的影响。方法:选取Wistar大鼠,随机分为正常、模型、生用、醋炙、酒炙、蜜炙及阳性对照组,采用40%CC14制备大鼠慢性肝损伤模型,同时ig北柴胡不同炮制品(均为5 g.kg-1)进行干预,连续8周。测定大鼠血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBiL)、白蛋白(Alb)、总蛋白(TP)水平,并计算白蛋白与球蛋白比值(A/G)。采用胆总管插管术,观察北柴胡不同炮制品对大鼠胆汁流量的影响。结果:北柴胡醋炙组ALT,AST,ALP,TBiL含量降低最为显著(P<0.01);蜜炙组次之(P<0.05);生用组和酒炙组对ALT,AST,ALP含量有降低作用(P<0.05);醋炙组TP,Alb,A/G含量升高最为显著(P<0.01或P<0.05);蜜炙组能使TP,Alb含量升高(P<0.01或P<0.05);生用组和酒炙组仅能使TP含量升高(P<0.05)。北柴胡醋炙组胆汁流出量增加最为显著(P<0.05)。结论:北柴胡醋炙品疏肝利胆作用最强,蜜炙品次之,酒炙品与生柴胡作用相当。Objective： To explore the impact of different processing methods on soothing liver and. choleretic effects of Bupleurum chinense. Method： Wistar rats were randomly divided into normal, model, health products, vinegar products, wine products, honey products and positive control group. Chronic hepatic injury model of rat was induced by 40% CCl4. Then rats were treated with B. chinense and its processed products （both for 5 g ·kg ^- 1 ） for 8 weeks. Alanine aminotransferase （ ALT ） , aspartate aminotransferase （ AST ）, alkalinephosphatase （ALP）, total bilirubin （TBiL）, Albumin （Alb） and total protein （TP） levels were measured, and of the albumin and globulin ratio （A/G） was calculated. The common bile duct was incubated, and the flow of bile was detected. Result： ALT, AST, ALP and TBiL contents in B. chinense vinegar product group was reduced significantly （P 〈0.01） ; honey productranked the second place （P 〈 0.05） ; ALT, AST and ALP contents of health product and wine product groups had a lowered effect （P 〈 0.05）. TP, Alb and A/G contents in vinegar product group was increased significantly （P 〈 0.01 or P 〈 0.05） ; Honey product increased TP and Alb contents （P 〈 0. 01 or P 〈 0.05 ） ; health product and wine product increased TP content （ P 〈 0.05 ）. The bile flow of vinegar product group increased significantly （ P 〈 0.05 ）. Conclusion The soothing liver and choleretic effects of B. chinense vinegar product are the strongest, honey product is the second, and wine product and health product effect is fair.

关 键 词：北柴胡 炮制 疏肝 利胆 

分 类 号：R285.5[医药卫生—中药学]