补阳还五汤干预中风先兆证的Meta分析  

Meta Analysis of Buyang Huanwu Decoction Intervening Prodromal Symptoms of Stroke

作　　者：徐谦[1] 陈新林[1] 沈耿[1] 莫传伟[1] 李先涛[1] 

机构地区：[1]广州中医药大学,广州510006

出　　处：《中国实验方剂学杂志》2013年第16期339-343,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81072733)

摘　　要：目的:评价补阳还五汤干预中风先兆证的有效性及安全性。方法:采用文献系统评价定性研究与定量Meta分析相结合的方法与技术,检索中国期刊全文数据库、维普中文期刊数据库、万方学术期刊全文数据库1990年1月至2012年12月国内20年间的相关文献,收集补阳还五汤干预中风先兆证的随机对照试验(RCTs)。结果:按纳入和排除标准筛选高质量的研究论著、提取有效数据,最终纳入5个临床随机对照试验,采用RevMan 4.2软件进行Meta分析,结果显示,补阳还五汤干预中风先兆证有效率优于对照组[OR=4.44,95%CI(2.52,7.83)];补阳还五汤降低全血黏度和血浆比黏度的效果优于对照组[3个试验的高切全血黏度-0.69,95%CI(-0.79,-0.58),低切全血黏度-1.17,95%CI(-1.37,-0.96),血浆比黏度-0.18,95%CI(-0.23,-0.14)]。结论:Meta分析初步证实补阳还五汤能有效干预中风先兆证。Objective： To evaluate the effect of Buyang Huanwu decoction intervening prodromal symptoms of stroke. Method： We searched CNKI, VIP, WanFang （1990 to 2012） for randomized control trials about Buyang Huanwu decoction intervening prodromal symptoms of stroke. Result： According to the inclusion and exclusion criteria and assessment the quality of included trials, the extraction of effective data, 5 randomized clinical trials and their efficiency were evaluated, statistical analysis was conducted by using RevMan 4.2 software. （~）Meta analysis showed that the efficiency of Buyang Huanwu decoction on prodromal symptoms of stroke was better than the control group [OR =4.44, 95% CI （2.52, 7.83）]; （~） The indexes of high and low shear on hemorheology were evaluated, plasma viscosity was evaluated, Meta analysis results showed that the Buyang Huanwu decoction reduced the whole blood viscosity and plasma viscosity were better than the control group. Conclusion： The Buyang Huanwu decoction intervening prodromal symptoms of stroke was effective.

关 键 词：补阳还五汤 中风先兆证 META分析 

分 类 号：R287[医药卫生—中药学]