Graves病患者血清TRAb的检测与临床应用  

Detection of sera TRAb in patients with Graves' disease

作　　者：刘小弟[1] 褚玉[2] 张黎铭[1] 黄耀章[1] 

机构地区：[1]上海市第一人民医院,200080 [2]宁波市第二医院

出　　处：《宁波医学》2000年第2期64-65,共2页

摘　　要：目的　探寻促甲状腺激素受体抗体 (TRAb)与Graves病 (GD)的关系 ,了解TRAb活性与甲状腺功能亢进症的内在联系。　方法　采用放射受体分析法检测GD患者 (分甲亢组和缓解组 )以及健康人血清TRAb。　结果　GD甲亢组、缓解组及正常对照组的TRAb活性分别为 2 8.3± 2 2 .1,5 .6± 3.2和1.8± 0 .9U/L ;GD组明显高于正常对照组 ,GD甲亢组明显高于缓解组。GD甲亢组TRAb、甲状腺球蛋白抗体 (TGAb)、甲状腺微体抗体 (TMAb)阳性检出率分别为 81.4%、6 0 .5 %和 5 3.5 %。GD患者血清TRAb活性与FT3,FT4 及TSH浓度之间均无显著相关性。　结论　检测TRAb不能反映GD甲亢严重程度 。Objective To explore the relationship between Grave's disease (GD) and thyrotropin receptor antibodies (TRAb). Methods TRAb activities were assessed in 79 patients with GD and 30 control subjects by radio-receptor assay. Results The activities of TRAb in hyperthyroid GD、remittent GD and control were 28.3± 22.1 、5.6±3.2 and 1.8±0.9 U/L, respectively. Hyperthyroid GD group was significantly higher compared with remittent GD, while it was higher in the latter than in control. Positive rate of TRAb、TGAb、TMAb in hyperthyroid GD group were 81.4%、60.5% and 53.5%, respectively. There was no statistical correlation betweem TRAb activities and FT3 or FT4 concentration. Conclusion TRAb activity could not reflect the severity of hyperthyroidism, but could help the diagonsis and treatment of GD.

关 键 词：促甲状腺素受体抗体 Granes病 血清诊断 TRAB 

分 类 号：R581.104[医药卫生—内分泌] R446.62[医药卫生—内科学]