献血人群感染乙肝、丙肝病毒的血液接触危险因素研究  

Investigation of risk factors of blood donors infected with HBV and HCV

作　　者：陈雪[1] 何翠[2] 席光湘[1] 张杰[1] 田莉[1] 邓小倩[2] 罗利平[2] 万浬科[1] 何毅[1] 

机构地区：[1]成都市血液中心,四川成都610041 [2]成都医学院

出　　处：《现代预防医学》2013年第16期2967-2971,共5页Modern Preventive Medicine

基　　金：四川省卫生厅科研项目(050169);成都市卫生局年重大科技攻关课题(0915)

摘　　要：目的通过对献血者感染乙型肝炎以及丙型肝炎病毒危险因素的研究,探讨血液接触行为的危险性。方法对485例HBsAg检测阳性、305例抗-HCV抗体检测阳性的献血者及1581例两者检测阴性的献血者进行病例对照研究,应用多因素条件Logistic回归模型分析与感染乙肝病毒、丙肝病毒有关的血液接触危险行为,并对危险行为的人群归因危险度(PAR)进行估计。结果筛选出6个与乙肝病毒感染有关的血液接触危险行为:10年前肌肉注射史、乙肝家族史、使用共用剃刀、穿耳环孔史、牙科治疗史、针灸史,其人群归因危险度分别是0.449,0.066,0.251,0.092,0.129,0.038,综合人群归因危险度为68%;7个与丙肝病毒感染有关的危险行为:使用共用剃刀、输血史、乙肝家族史、纹身史、牙科治疗史、穿耳环孔史、10年前肌肉注射史,其人群归因危险度分别是0.351,0.024,0.089,0.063,0.163,0.078,0.149,综合人群归因危险度是62%。结论献血人群感染乙肝、丙肝病毒的血液接触危险行为有使用共用剃刀、乙肝家族史、输血史、10年前肌肉注射史、纹身史、牙科治疗史等,避免以上血液接触危险行为,可减少感染乙肝、丙肝病毒的几率。OBJECTIVE To investigate the relationship of risk factors of blood contact and blood donors infected with HBV and HCV virus. METHODS A case-control study was carried out, which included 484 HBsAg positive blood donors, 305 anti-HCV positive blood donors and 1 581 negative blood donors. The data were analyzed by means of logistic regression method, and population attributable risk （PAR） was estimated. RESULTS According to the multiple condition logistic re- gression model, intramuscular injections before 10 years, hepatitis B family history, sharing a razor, ear piercing, dental care and acupuncture increased the risk of HBV infection, and the OR values for the items were 0.449, 0.066, 0.251, 0.092, 0.129 and 0.038, respectively, and the total PAR was 68%. Sharing a razor, blood transfusion, hepatitis B family history, tattooing, dental care, ear piercing, and intramuscular injections before 10 years increased the risk of HCV infec- tion, and the OR values for the items were 0.351, 0.024, 0.089, 0.063, 0.163, 0.078 and 0.149, respectively, and the total PAR was 62%. CONCLUSION The blood contacting risk factors of blood donors infected with HBV and HCV virus in- eludes sharing a razor, hepatitis B family history, blood transfusion, intramuscular injections before 10 years, tattooing, dental care, etc. It＇s important for blood donors to avoid these risk factors of blood contact to reduce the risk of infection of HBV, HCV.

关 键 词：血液接触 人群归因危险度 献血人群 

分 类 号：R181.36[医药卫生—流行病学]