钠离子电导对螺旋波稳定性的影响  

Effect of the Sodium Ion Conductance on the Stability of Spiral Wave:Theoretical Analysis by Numerical Simulation

作　　者：孙旭阳[1] 李莉[2] 陆阳[2] 

机构地区：[1]中国医科大学基础医学院生物医学工程教研室,沈阳110001 [2]中国医科大学基础医学院生物物理教研室,沈阳110001

出　　处：《中国医科大学学报》2013年第7期653-656,共4页Journal of China Medical University

基　　金：沈阳市科技计划(F11-262-9-16)

摘　　要：目的基于计算机模拟实验探索钠离子电导对螺旋波稳定性的影响。方法运用计算机仿真技术模拟一维和二维心肌组织的电生理活动,分别以动作电位时程恢复性质曲线,螺旋波波头轨迹和环长Poincare散点图为观察对象,探寻钠离子电导与螺旋波稳定性的关系。结果在一维组织中,动作电位时程恢复曲线的斜率随着钠离子电导增大而增大,但总体影响不大。在二维组织中,随着钠离子电导的增大螺旋波波头的轨迹趋于稳定,环长更小,环长Poincare散点图更加汇聚。结论钠离子电导增大可使螺旋波的稳定性增高。Objective To analyze the effect of the sodium ion conductance on the stability of spiral wave by using numerical simulation. Methods The computer simulation technology was used to simulate the electrophysiological activity of the one-dimensional and the twodimensional myocardial tissue. APD restitution curve,trajectories of the spiral tip and Poincare plots of the successive cycle lengths （CL） of the spiral waves was observed,ken the relationship between the sodium ion conductance and the stability of spiral wave was analyzed. Results Within a certain range, the slope of APD restitution curve increased with the increase of sodium ion conductance in the onedimensional tissue. However, the overall impact was little. Trajectories of the spiral tip became more regular, cycle lengths became short, and the cycle length Poincare plots were highly ordered in the two-dimensional tissue. Conclusion Within a certain range,the increase of the sodium ion conductance can increase the stabihty of spiral wave.

关 键 词：螺旋波 动作电位时程 螺旋波波头轨迹 环长Poincare散点图 计算机模拟 

分 类 号：R912[医药卫生—药学]