不同类型树脂对4种丹参酚酸类成分的动态吸附研究  

Dynamic adsorption of different resins for four salvianolic acids from Salviae miltiorrhizae Radix et Rhizoma

作　　者：郑云枫[1] 黄利[1] 魏娟花[1] 彭国平[1] 李贺敏[1] 程建明[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210029

出　　处：《中成药》2013年第8期1648-1652,共5页Chinese Traditional Patent Medicine

基　　金：江苏省自然科学基金(SBK201123752);校科技创新风险基金项目(CX201101)

摘　　要：目的研究3种不同类型树脂对丹参4种水溶性成分(丹参素、原儿茶醛、丹酚酸D、丹酚酸B)的动态吸附特性。方法通过动态吸附及解吸附实验,以4种丹酚酸成分为考察指标,综合比较了大孔树脂、聚酰胺树脂及阴离子交换树脂对各成分的动态泄露曲线、吸附饱和量、动态解吸附曲线和解吸附率。结果 AB-8型大孔树脂适宜于丹酚酸D和丹酚酸B精制分离,其饱和吸附量分别为22.3 mg/g和27.4 mg/g,与聚酰胺树脂相近,远高于201×7型阴离子交换树脂;而阴离子交换树脂对丹参素与原儿茶醛的吸附效果较好,饱和吸附量分别为30.8 mg/g和3.2 mg/g,优于另外两种树脂。结论大孔树脂和阴离子交换树脂在丹参酚酸精制分离时具有互补性,两者联合应用能产生更好的效果。AIM To study the adsorption properties of the three different resins for the four salvianolic acids（danshensu,protocate chualdehyde,salvianolic acid D and salvianolic acid B）.METHODS Four salvianolic acids were employed as markers to evaluate adsorption leaking curves,dynamic adsorption capacities,desorption curves and desorption ratios on three different resins（macroporous resin,polyamide resin and anion exchange resin）.RESULTS AB-8 macroporous resin was a suitable resin to purify salvianolic acid D and salvianolic acid B,and their dynamic adsorption capacities,similar to polyamide resin and much higher than 201×7 type anion resin,were 22.3 mg/g and 27.4 mg/g,respectively.The dynamic adsorption capacities of danshensu and protocate chualdehyde on anion exchange resin which were 30.8 mg/g and 3.2 mg/g,respectively,were greater than those of other two resins.CONCLUSION Combination of macroporous resin with anion exchange resin to separate and purify salvianolic acids is feasible and necessary.

关 键 词：丹参酚酸 大孔树脂 聚酰胺树脂 阴离子交换树脂 动态吸附 

分 类 号：R284.2[医药卫生—中药学]