老年慢性阻塞性肺疾病急性加重患者肠黏膜屏障功能变化的临床研究  

The intestinal mucosal barrier function in elderly patients with acute exacerbations of chronic obstructive pulmonary disease

作　　者：温燕[1] 李小美[1] 李家树[1] 

机构地区：[1]江苏省连云港市第一人民医院呼吸内科,222000

出　　处：《实用医学杂志》2013年第16期2600-2602,共3页The Journal of Practical Medicine

基　　金：江苏省连云港市卫生局基金项目(编号:1305)

摘　　要：目的:探讨老年慢性阻塞性肺疾病急性加重(AECOPD)患者肠黏膜屏障功能变化及其与疾病严重程度的关系。方法:受试者按标准分为通气组、非通气组及对照组。入组后行APACHE II评分,检测血清D-乳酸、DAO、PCT水平并分析。结果:血清D-乳酸、DAO、PCT、APACHE II水平在试验组高于对照组,非通气组低于通气组但高于对照组;相关分析显示试验组患者血清D-乳酸、DAO与PCT均呈正相关。结论:老年AECOPD患者存在肠黏膜屏障功能损害,且病情越重肠黏膜损害越重。Objective To assess the intestinal mucosa barrier function in elderly patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） and to analyze its relationship with the severity of AECOPD. Methods Subjects were divided into ventilation group, no-ventilation group and control group according to the standard. Then APACHE II score of all the subjects was assessed ; and the serum D-lactate, DAO and PCT were detected. Results The serum levels of D-lactate, DAO and PCT and APACHE II score in ventilation group and no-ventilation group were higher than those in control group; and those in ventilation group were higher than those in no-ventilation group. There were positive correlations among the serum levels of D-lactate, DAO and PCT in treatment group. Conclusion Intestinal mucosa barrier may have been injured in elderly patients with AECOPD, and would get worse as the severity of AECOPD increase.

关 键 词：肺疾病 慢性阻塞性 急性加重期 肠黏膜屏障 降钙素原 

分 类 号：R563.9[医药卫生—呼吸系统]