小儿肺炎血清胱抑素C检测的临床价值  

Clinical value of serum cystatin C in infantile pneumonia

作　　者：王秀丽[1] 陈正徐[2] 刘进生[1] 

机构地区：[1]合肥市第二人民医院儿科,230011 [2]合肥市第二人民医院检验科,230011

出　　处：《中国小儿急救医学》2013年第4期373-375,共3页Chinese Pediatric Emergency Medicine

基　　金：合肥市科技局科技计划项目（合科[2011]25号）

摘　　要：目的探讨肺炎患儿不同时期的血清胱抑素C（cystatinC，Cysc）变化及其临床价值。方法对2012年11月至2013年3月收治的92例肺炎患儿（轻症肺炎组59例，重症肺炎组33例），分别于急性期和恢复期检测血清CysC、血肌酐、尿素等指标，同时检测40例健康儿童作为对照组，并对临床病情分度和转归进行对比分析。结果重症肺炎组急性期血CysC平均含量（1．98±0．33）mg／L，显著高于对照组（0．85±0．24）mg／L，差异有统计学意义（P〈0．01）；恢复期血CysC平均含量（1．12±0．23）mg／L，与对照组比较差异无统计学意义（P〉0．05），急性期与恢复期比较差异有统计学意义（P〈0．05）。轻症肺炎组急性期和恢复期血CysC平均含量分别为（1．10±0．22）mg／L和（0．94±0．21）mg／L，与对照组比较，差异均无统计学意义（P〉0．05）。重症肺炎组急性期血CysC异常检出率为51．9％（14／27），显著高于血尿素和肌酐的异常检出率3．7％（1／27），差异有统计学意义（P〈0．01）。结论重症肺炎对小儿肾功能有损害，但这种损害是可逆性的。血CysC测定对伴有肾功能损害的重症肺炎的早期诊断及疗效判断均具有参考价值。Objective To explore the clinical value of the serum cystatin C （ Cys C） changes in dif-ferent periods of the infantile pneumonia. Methods Ninety-two cases of infantile pneumonia （59 mild pneu-monia patients and 33 severe pneumonia patients） from November 2012 to March 2013 were collected and 40 cases of healthy infant were enrolled for control group. The levels of serum Cys C, urea and creatinine in acute and recovery period were detected. Results In severe pneumonia patients, the average level of Cys C in acute period [ （ 1.98 ±0. 33） mg/L ] is significantly higher than that in control group [ （0. 85 ± O. 24） mg/L ] （P 〈0. O1 ）, and there was no significant difference between recovery period [ （ 1.12 ± O. 23 ） mg/L] and control group （ P 〉 O. 05 ）, and there was significant difference between acute and recovery period （ P 〈 O. 05 ）. In mild pneumonia patients, there were no significant differences in the level of Cys C between the acute period [ （ 1.10 ±0. 22） mg/L] and recovery period [ （0. 94 ± O. 21 ） mg/L] as well as control group （P 〉 O. 05 ）. The .positive rate of Cys C in severe pneumonia patients （51.9%, 14/27 ） was higher than that of urea and creatinine （ 3.7%, 1/27） （ P 〈 O. 01 ）. Conclusion Severe pneumonia could result in renal dys-function, which is reversible. Cys C can be the clinical reference for early diagnosis and the therapeutic effect in severe pneumonia patients with renal dysfunction.

关 键 词：胱抑素C 小儿肺炎 肾功能损害 

分 类 号：R72[医药卫生—儿科]