N末端B型利钠肽原在老年慢性心力衰竭患者治疗评估作用研究  

Study of NT-pro-BNP on assessment of elderly patients with chronic heart failure

作　　者：陈锐[1] 毛一歆 任坤[1] 岳凡[1] 叶人诵[1] 钱俨[1] 

机构地区：[1]上海市第八人民医院老年科,上海200235

出　　处：《医药论坛杂志》2013年第7期4-5,共2页Journal of Medical Forum

摘　　要：目的通过连续2年观察两组患者心血管终点事件:心血管死亡、任何心血管事件的住院(心衰、急性冠脉综合征、脑血管意外、任何需要增加药物的院外失代偿心衰的发作)。方法研究入组180例患者采用随机单盲分为:BNP组与对照组。结果两组的全因死亡率无差异,BNP组明显减少因心衰再住院率(P<0.05),BNP组院外强化使用抗心衰药物患者的比例高于对照组(P>0.05),BNP组脑血管意外的发生率低于对照组(P>0.05),BNP组ACS发病率低于对照组(P<0.05)。结论以BNP指导的老年慢性心力衰竭患者的管理模式中在因心衰再入院方面优于常规的管理模式,并在预防ACS脑血管意外发生方面有一定优势,值得临床借鉴。Objective In this study group of 180 patients randomized, single blind divided into：BNP group and control group. Methods Through the continuous 2 years observing two groups of patients with cardiovascular endpoint events： any cardiovascular death, cardiovascular events in hospital （heart failure, acute coronary syndrome and cerebrovascular accident any need to increase the drug outside of the onset of decompensated heart failure） Results No difference in all cause mortality between the two groups, the BNP group decreased significantly due to heart failure hospitalization rate （ P 〈 0. 05 ）, BNP group lobbying uses the proportion of patients with heart failure drugs resistance Was higher than that of the control group （ P 〉 O. 05 ）, BNP group, the incidence of cerebrovascular accident was lower than that of the control group （ P 〉 0. 05 ）, BNP ACS disease incidence was lower than that of the control group （ P 〈 0. 05 ）. Conclusion Un der the guide of BNP in elderly patients with chronic heart failure management model in terms of readmission for heart failure is better than that of the conventional management mode, and has certain advantages in prevention of ACS cerebro vascular accident, is worthy of reference for clinical.

关 键 词：NT—pro—BNP 老年慢性心力衰竭 预后 

分 类 号：R541.6[医药卫生—心血管疾病]