阿托伐他汀对急性冠脉综合征患者血小板的影响  

Effect of different dosages of atorvastatin on function of platelet activity in acute coronary syndrome

作　　者：邓仁生[1] 秦梓良[1] 罗晓丽[1] 申源生[1] 刘锦光[1] 

机构地区：[1]惠州市中心人民医院心内科,广东惠州516001

出　　处：《医药论坛杂志》2013年第7期6-7,共2页Journal of Medical Forum

摘　　要：目的观察不同剂量阿托伐他汀对急性冠脉综合征(ACS)患者血小板活性的影响。方法 64例ACS患者随机分为对照组31例(阿托伐他汀20mg/d)和强化组33例(阿托伐他汀80mg/d)。治疗4周,测定两组治疗前后的血小板血栓烷B2(TXB2)、血小板α颗粒膜蛋白-140(GMP–140)、肝肾功能、心肌酶、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、高敏C反应蛋白(hs-CRP),采用SPSS15.0统计分析软件比较两组间差异。结果两组治疗后TXB2、GMP-140、TC、TG、LDL-C、hs-CRP血浆水平均比治疗前下降,治疗前后组内及组间比较均有显著性差异;两组PLT计数治疗前后及组间比较无显著差异。结论早期强化阿托伐他汀治疗ACS有更强的降脂作用,同时有抑制血小板活化及聚集作用,并随剂量的增加而加强。Objective To study the effect of different dosages of atorvastatin on the function of platelet activity in acute coronary syndrome. Methods Totally 64 ACS patients with acute coronary syndrome were randomly divided into control group （ atorvastatin 20mg/d n = 31 ） or high dosage group （ atorvastatin 80mg/d n = 33 ）. TC, LDL - C, HDL - C, TG, hs - CRP, Hepatic and renal functions, cardiac creatase,TXB2, GMP - 140 were assayed before and 4 weeks after treatment in two groups. Results In both group TC, LDL - C, TG, hs - CRP, TXB2, GMP - 140 were obviously decreased com- pared with those before treatment. High dosage group was better than the control group（ P 〈 0. 05 ）. The quantity of plate- lets was not decreased after treatment in both groups （P 〉 0. 05 ）. Conclusion It is suggested that atorvastatin intensive treatment could lower cholesterols more obviously. High dosage of atorvastatin had a better effect on inhibition of platelet activation and aggregation.

关 键 词：急性冠脉综合征 血小板活性 阿托伐他汀 强化降脂 

分 类 号：R541.4[医药卫生—心血管疾病]