数字化微喷技术制备阿莫西林-PLGA微囊  

Preparation of Amoxicillin PLGA Microcapsules by Digital Micro-jetting Technology

作　　者：孙怀远[1,2] 孙陈杰[1] 郑刚[1] 廖跃华[2] 崔俐俊[2] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093 [2]上海医疗器械高等专科学校,上海200093

出　　处：《中国医药工业杂志》2013年第8期770-773,共4页Chinese Journal of Pharmaceuticals

基　　金：上海市教育委员会科研创新项目(12YZ195)

摘　　要：以聚乳酸-羟基乙酸共聚物(PLGA)为囊材,应用数字化微喷射技术,采用内径40 m的喷头制备了阿莫西林-PLGA微囊。用正交试验优化得到的工艺为:PLGA溶液浓度为3%、微喷系统驱动电压80 V、喷射频率10 kHz和搅拌转速750 r/min。所得制品的平均粒径为(60.25±1.08)m,包封率和载药量为62.4%和2.1%,在体外30 d的累积释放率为85.4%。The amoxicillin PLGA microcapsules were prepared by digital micro-jetting technology with a sprinkler with the inner diameter of 40 μm. The optimal preparation obtained by orthogonal test were as follows： PLGA concentration was 3 %, driving voltage was 80 V, jet frequency was 10 kHz and agitator rotational speed was 750 r/min. The particle size, encapsulation efficiency and drug loading of the product were （60.25±1.08）μm, 62.4% and 2.1%, respectively. The in vitro cumulative amount at 30 d was 85.4 %.

关 键 词：数字化微喷射 阿莫西林 微囊 PLGA 制备 

分 类 号：R944.9[医药卫生—药剂学]